Molecular imaging

Details Molecular imaging Molecular imaging

1994-05-20

1995-09-26

Spear, Frank

Liquid purification or separation

Processes

Liquid/liquid solvent or colloidal extraction or diffusing...

2105021, B01D 1508

Patent

active

054531993

ABSTRACT:
Disclosed are chemically-produced specific binding, "molecular imaged" sorbents which reversibly bind a preselected macromolecule by spacially matched multipoint interactions between functional groups synthesized on the surface of the sorbent and functional groups on the surface of the macromolecule. Also disclosed are methods of producing such sorbents. The sorbents typically are high surface area solids comprising surface binding regions which have charged groups, metal coordinating groups, hydrophobic moities, or various combination thereof anchored thereto and spaced in the mirror image of complementary interactive groups on a surface of the macromolecule.

REFERENCES:
patent: 4623716 (1986-11-01), Stevenson et al.
patent: 4667024 (1987-05-01), Sitrin et al.
patent: 4696981 (1987-09-01), Harada et al.
patent: 4722999 (1988-02-01), Handschumacher et al.
patent: 4740306 (1988-04-01), Litwack et al.
patent: 4859611 (1989-08-01), Groopman et al.
patent: 4859765 (1989-08-01), Nestor, Jr. et al.
patent: 4963263 (1990-10-01), Kauvar
patent: 4970156 (1990-11-01), Avrameas et al.
patent: 4996296 (1991-02-01), Pecht et al.
patent: 4999291 (1991-03-01), Souza
patent: 5004802 (1991-04-01), Kluft
patent: 5010175 (1991-04-01), Rutter et al.
patent: 5011777 (1991-04-01), Shoyab et al.
patent: 5019270 (1991-05-01), Afeyan et al.
patent: 5030352 (1991-07-01), Varady et al.
patent: 5039488 (1991-08-01), Kohr
patent: 5043278 (1991-08-01), Nagaoka et al.
patent: 5047512 (1991-09-01), Handschumacher et al.
patent: 5049656 (1991-09-01), Lewis et al.
patent: 5057223 (1991-10-01), Della Valle et al.
patent: 5059654 (1991-10-01), Hou et al.
patent: 5077393 (1991-12-01), Hayashi
patent: 5079155 (1992-01-01), Cox et al.
patent: 5110833 (1992-05-01), Mosbach
Andersson et al., "Enantiomeric Resolution on Molecularly Imprinted Polymers Prepared with only Non-Covalent and Non-Ionic Interactions", J. of Chromatography, 516:313-322 (1990).
Andersson et al., "Molecular Recognition in Synthetic Polymers: Preparation of Chiral Stationary Phases by Molecular Imprinting of Amino Acid Amides", J. of Chromatography, 513 (1990) pp. 167-179.
Andersson, et al., "Enantiomeric Resolution of Amino Acid Derivatives on Molecularly Imprinted Polymers as Monitored by Potentiometric Measurements", J. of Chromatography, 516 (1990) pp. 323-331.
Bock et al., "Selection of Single-Stranded DNA Molecules that Bind and Inhibit Human Thrombin", Nature, vol. 355, Feb. 1992, pp. 564-566.
Mehra et al., "Efficient Mapping of Protein Antigenic Determinants", Proc. Natl. Acad., 83:7013-7017 (1986).
Norrlow et al, "Improved Chromatography: Prearranged Distances Between Boronate Groups by the Molecular Imprinting Approach", J. of Chromatography, 396:374-377 (1987).
Sellergren, Borje, "Molecular Imprinting by Noncovalent Interactions: Tailor-Made Chiral Stationary Phases of High Selectivity and Sample Load Capacity", Chirality, 1:63-68 (1989).
Sellergren et al., "Highly Enantioselective and Substrate-Selective Polymers Obtained by Molecular Imprinting Utilizing Noncovalent Interactions. NMR and Chromatographic Studies on the Nature of Recognition", J. Am. Chem. Soc., 110:5853-5860 (1988).
Sellergren et al., "Molecular Imprinting of Amino Acid Derivatives in Macroporous Polymers", J. of Chrom., 347:1-10 (1985).
Welling et al., "Synthetic Antibody Fragment as Ligand in Immunoaffinity Chromatography", J. of Chromatography, 512:337-343 (1990).

Affiliated with

Also associated with

Rating

Molecular imaging does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Molecular imaging, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Molecular imaging will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1550529