Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Implant or insert
Reexamination Certificate
2009-02-13
2011-12-20
Zemel, Irina S (Department: 1765)
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Implant or insert
C424S426000, C424S484000, C424S488000, C525S054100, C525S054200, C525S326100, C525S420000, C525S540000, C623S011110, C623S013110
Reexamination Certificate
active
08080260
ABSTRACT:
A composition comprising a human- or animal-derived extracellular matrix and a macromolecular network which is prepared ex vivo is provided that is useful in the repair of a tissue injury, particularly in repair of tears or gaps between a tendon and a bone, such as in a rotator cuff tear. In an embodiment, the composition comprises a human- or animal-derived extracellular matrix having impregnated therein a macromolecular network of hyaluronan macromolecules that have been cross-linked via dihydroxyphenyl linkages, so that the cross-linked network is interlocked within the extracellular matrix. The resulting HA-incorporated extracellular matrix can be supplied in the form of a patch to reinforce a tissue repair or cover a tissue defect.
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Calabro Anthony
Chin LiKang
Derwin Kathleen Anne
Iannotti Joseph Patrick
Pearne & Gordon LLP
The Cleveland Clinic Foundation
Zemel Irina S
LandOfFree
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