Molecular diagnosis of atypical mycobacterial infections

Details Molecular diagnosis of atypical mycobacterial infections Molecular diagnosis of atypical mycobacterial infections

2006-07-11

2006-07-11

Horlick, Kenneth R. (Department: 1637)

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

C536S024320, C435S091200

Reexamination Certificate

active

07074568

ABSTRACT:
The present invention provides methods for diagnosing mycobacteria other than tuberculosis (MOTT) infections in patients comprising amplifying the internal transcribed spacer sequence (ITSS) of 16S-23S rDNA of MOTT with primers that amplify MOTT but notMycobacteria Tuberculosis(MTB). The present invention also provides a method for differentiating between MOTT and MTB infections comprising amplifying MOTT with primers that amplify MOTT but not MTB; amplifying MTB with primers that amplify MTB but not MOTT; and detecting approximately 130 base pair product indicative of MOTT and approximately 180 base pair product indicative of MTB.

REFERENCES:
patent: 5731150 (1998-03-01), Sandhu et al.
patent: 5776693 (1998-07-01), Guesdon et al.
patent: 6670130 (2003-12-01), Kim et al.

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