Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Patent
1988-05-13
1991-05-14
Wax, Robert A.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
436501, 436811, 536 27, 935 19, 935 77, 935 78, C12Q 168, G01N 33533
Patent
active
050155709
ABSTRACT:
A method for diagnosing Alzheimer Disease or a predisposition to develop Alzheimer Disease in an individual, by determining the presence of an alteration in the normal base sequence of the 24 base pairs appearing at the end of the APC coding sequence of the preAPC gene, or in the normal base sequence of the corresponding mRNA, in the DNA or RNA or such individual. The method detects the presence of a frameshift mutation in the preAPC gene postulated to result in the synthesis of the APC protein. Accumulation of APC protein in the brain is a phenomenon of Alzheimer Disease. A variety of nucleic acid hybridization techniques are applicable to the determination of an alteration in the preAPC gene sequence of interest.
REFERENCES:
patent: 4666829 (1987-05-01), Glenner et al.
Kang et al., (1987) Nature, vol. 325, pp. 733-736.
Kamarck Michael E.
Rae Peter M. M.
Scangos George A.
Unterbeck Axel J.
Marschel Ardin H.
Molecular Therapeutics, Inc.
Wax Robert A.
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