Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Reexamination Certificate
2006-12-26
2006-12-26
Russel, Jeffrey Edwin (Department: 1654)
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
C546S048000, C548S204000, C549S275000, C549S278000, C549S510000, C552S546000
Reexamination Certificate
active
07153946
ABSTRACT:
A molecular conjugate is provided having the formula:wherein R1is a de-hydroxyl or de-amino moiety respectively of a hydroxyl-bearing or amino-bearing biologically active molecule or an analog or derivative thereof, and Z is —O— or —NH—, respectively, Y is a straight or branched alkyl having 1 to 20 carbons that may be optionally substituted with one or more phenyl, a cycloalkyl optionally substituted with one or more alkyl or phenyl, or an aromatic group optionally substituted with one or more alkyl groups, electron-withdrawing groups, or electron-donating groups; and R2is —CH═CH(W), —CH(OH)CH(OH)W, or —C(O)H, where W can be H, a straight or branched alkyl having 1 to 20 carbons that may be optionally substituted with one or more phenyl, a cycloalkyl optionally substituted with one or more alkyl or phenyl, or an aromatic group optionally substituted with one or more alkyl groups, electron-withdrawing groups, or electron-donating groups.
REFERENCES:
patent: 4358391 (1982-11-01), Finkelmann et al.
patent: 4522750 (1985-06-01), Ades et al.
patent: 4625014 (1986-11-01), Senter et al.
patent: 4631190 (1986-12-01), Shen et al.
patent: 4886780 (1989-12-01), Faulk
patent: 5108987 (1992-04-01), Faulk
patent: 5144011 (1992-09-01), Shen et al.
patent: 5254342 (1993-10-01), Shen et al.
patent: 5354844 (1994-10-01), Beug et al.
patent: 5387578 (1995-02-01), Angelucci et al.
patent: 5393737 (1995-02-01), Mayers et al.
patent: 5501854 (1996-03-01), Raso
patent: 5527527 (1996-06-01), Friden
patent: 5571082 (1996-11-01), Bashikirov
patent: 5599908 (1997-02-01), Raso
patent: 5603931 (1997-02-01), Raso
patent: 5614487 (1997-03-01), Battersby et al.
patent: 5672683 (1997-09-01), Friden et al.
patent: 5675025 (1997-10-01), Sisti et al.
patent: 5684175 (1997-11-01), Sisti et al.
patent: 5688977 (1997-11-01), Sisti et al.
patent: 5728383 (1998-03-01), Johnson et al.
patent: 5750737 (1998-05-01), Sisti et al.
patent: 5762932 (1998-06-01), Kemp
patent: 5770745 (1998-06-01), Swindell et al.
patent: 5795560 (1998-08-01), Reed
patent: 5808113 (1998-09-01), Murray et al.
patent: 5833988 (1998-11-01), Friden
patent: 5939566 (1999-08-01), Swindell et al.
patent: 5948919 (1999-09-01), Sisti et al.
patent: 5973170 (1999-10-01), Sisti et al.
patent: 5977307 (1999-11-01), Friden et al.
patent: 6015555 (2000-01-01), Friden
patent: 6027921 (2000-02-01), Heartlein et al.
patent: 6048990 (2000-04-01), Liang et al.
patent: 6066749 (2000-05-01), Sisti et al.
patent: 6072060 (2000-06-01), Swindell et al.
patent: 6077834 (2000-06-01), Cheng
patent: 6107497 (2000-08-01), Sisti et al.
patent: 6133462 (2000-10-01), Sisti et al.
patent: 6136999 (2000-10-01), Chander et al.
patent: 6143902 (2000-11-01), Zygmunt et al.
patent: 6150327 (2000-11-01), Sinn et al.
patent: 6171612 (2001-01-01), Byk et al.
patent: 6191290 (2001-02-01), Safavy
patent: 6262281 (2001-07-01), Swindell et al.
patent: 6307088 (2001-10-01), Swindell et al.
patent: 2001/0000488 (2001-04-01), Mather
patent: 0 624 377 (1994-11-01), None
patent: 1 033 372 (2000-09-01), None
patent: WO 97/44026 (1997-11-01), None
patent: WO 98/19705 (1998-05-01), None
patent: WO 98/52614 (1998-11-01), None
patent: WO 99/22728 (1999-05-01), None
Yeh, et al., “Killing of Human Tumor Cells in Culture with Adriamycin Conjugates of Human Transferrin”, Clin. Immunol. Immunopathol. 32, 1-11 (1984).
Sizensky et al., “Characterization of the Anti-Cancer Activity of Transferrin-Adriamycin Conjugates”, Am.J. Reprod. Immunol. 27:163-166 (1992).
Kratz, et al., “Transferrin Conjugates of Docurubicin: Synthesis, Characterization, Cellular Uptake, and in Vitro Efficacy”, J. Pharm Sci., 87, 338-346 (1998).
Tanaka, et al., “Synthesis of Transferrin-Mitomycin C Conjugate as a Receptor-Mediated Drug Targeting System”, Biol. Pharm. Bull. 19, 774-777 (1996).
Bicamumpaka, et al., “In Vitro Cylotoxicity of Paclitaxel-Transferrin Conjugate on H69 Cells”, Oncol. Rep., 5, 1381-1383 (1998).
Skehan, et al., “New Colorimetric Cytotoxicity Assay for Anticancer-Drug Screening”, J. Natl. Cancer Inst. 82: 1107-1112, (1990).
Likhitwitayawuid, et al., “Cytotoxic and Antimalarial Bisbenzylisoquinoline Alkaloids from Stephania Erecta”, J. Nat. Prod. 56: 30-38, 1993).
Ojima, et al., “Macrocycle Formation by Ring-Closing Metathesis Application to the Syntheses of Novel Macrocyclic Taxoids”, Journal of the American Chemical Society, 2000, vol. 122, pp. 5343-5353.
Singh, et al., “Transferrin Directed Delivery of Adriamycin to Human Cells”, Anticancer Research, 1998, vol. 18, pp. 1423-1428.
Ainsworth Sterling K.
Chander Madhavi C.
McChesney James D.
Siahaan Teruna J.
Xu Christine R.
Heller Ehrman LLP
Russel Jeffrey Edwin
Tapestry Pharmaceuticals, Inc.
LandOfFree
Molecular conjugates for use in treatment of cancer does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Molecular conjugates for use in treatment of cancer, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Molecular conjugates for use in treatment of cancer will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3666377