Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – 15 to 23 amino acid residues in defined sequence
Patent
1988-08-19
1992-09-22
Nucker, Christine M.
Chemistry: natural resins or derivatives; peptides or proteins;
Peptides of 3 to 100 amino acid residues
15 to 23 amino acid residues in defined sequence
530322, 530324, 530345, 530377, 5303911, 5303917, 5303919, 530408, 530409, 530410, 536 27, 536 28, 536 29, C07K 710, C07K 1702
Patent
active
051497824
ABSTRACT:
Molecular conjugates which facilitate the attachment of macromolecular drugs onto cellular surfaces and their entry into cells are described. The molecular conjugates comprise a macromolecular drug linked to an "inactivated" membrane blending agent which inserts into the cellular plasma membrane. The membrane blending agent is inactivated by cleavable linkage to a blocking agent which, until released from the conjugate under appropriate conditions, blocks and ability of the membrane blending agent to insert into the cellular membrane. Upon release of the blocking agent, the membrane blending agent is "activated" and the conjugate can be inserted into a cellular plasma membrane. The membrane blending agents can be peptides such as fusogenic or ion channel forming peptides or long chain fatty acids. The blocking agents can be bulky or charged moieties which mask and prevent insertion of the membrane blending agent.
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Chang Tse-wen
deVilliers Jean
Gordon Wayne
DeConti, Jr. Giulio A.
Kim Kay
Mirabel Eric P.
Nucker Christine M.
Tanox Biosystems, Inc.
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