Molecular cloning of the anhidrotic ectodermal dysplasia gene

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4353201, 536 331, C12N 1509, C07H 2104

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active

057009260

ABSTRACT:
The present invention relates to various yeast artificial chromosomes (YACs) which contain all or a portion of the human EDA gene for anhidrotic ectodermal dysplasia, probes specific for human EDA gene and methods of diagnosis of EDA gene-related disorders. The invention also relates to molecular cloning of the EDA gene.

REFERENCES:
patent: 5556786 (1996-09-01), Kere et al.
Kere et al. (1996) X-linked anhidrotic (hypohidrotic) ectodermal dysplasia is caused by mutation in a novel transmembrane protein, Nature Genetics 13 (4): 409-416, Aug. 13, 1996.
Clarke, A. et al., "X-linked Hypohidrotic Ectodermal Dysplasia:DNA probe Linkage Analysis and Gene Location" Hum. Genet. (1987) 75:378-380.
Freire-Maia et al., "Ectodermal Dysplasias: A Clinical and Genetic Study" (1984) (New York: Alan R. Liss).
Hanauer, A. et al., "Genetic Mapping of Anhidrotic Ectodermal Dysplasia: DXS159, a Closely Linked Proximal Marker" Hum. Genet. (1988) 80:177-180.
Kere, J., et al. "Anhidrotic Ectodermal Dysplasia Gene Region Cloned in Yeast Artificial Chromosomes" Genomics (1993) 16:305-310.
Kere, J., et al., "Gene Effect in Carriers of Anhidrotic Ectodermal Dysplasia", J. Med. Genet. (1966) 3:169-176.
Kolvraa, S. et al., "Close Linkage Between X-linked Ectodermal Dysplasia and a Cloned DNA Sequence Detecting a Two Allele Restriction Fragment Length Polymorphism in the Region Xp11-q12" Hum. Genet. (1986) 74:284-287.
Limon, J., et al "X-linked Anhidrotic Ectodermal Dysplasia and de novo t(X;1) in a Female" Hum. Genet. (1991) 87:338-340.
MacDermot, K.D., et al., "Gene Localization of X-linked Hypohidrotic Ectodermal Dysplasia (C-S-T syndrome)" Hum. Genet. (1986) 74:172-173.
Reed, W.B., et al. "Clinical Spectrum of Anhidrotic Ectodermal Dysplasia" Arch. Derm. (1970) 102:134-143.
Thomas, N.S.T. et al., "Characterisation of Molecular DNA Rearrangements Within the Xq12-q13.1 Region in Three Patients With X-linked Hypohidrotic Ectodermal Dysplasia (EDA)" Hum. Mol. Genet. (1993) 2:1679-1685.
Turleau, C., et al., "X-Linked Hypohidrotic Ectodermal Dysplasia and t(X;12) in a Female" Clin. Genet. (1989) 35:462-466.
Zonana, J. "Hypohidrotic (Anhidrotic) Ectodermal Dysplasia: Molecular Genetic Research and Its Clinical Applications" Semin. Dermatol. (1993) 12:241-246.
Zonana, J. et al. "Detection of a Molecular Deletion at the DXS732 Locus in a Patient with X-linked Hypohidrotic Ectodermal Dysplasia (EDA), with Identification of a Unique Junctional Fragment" Am. J. Hum. Genet. (1993) 52:78-84.
Zonana J., et al., "High Resolution Mapping of the X-linked Hypohidrotic Ectodermal Dysplasia Locus" Am. J. Hum. Genet. (1992) 51:1036-1046.
Zonana, J., et al. "Detection of de novo Mutations and Analysis of Their Origin in Families with X-linked Hypohidrotic Ectodermal Dysplasia" J. Med. Genet. (1994) 21:287-292.

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