Molecular cloning and characterization of a further gene sequenc

Details Molecular cloning and characterization of a further gene sequenc Molecular cloning and characterization of a further gene sequenc

1983-12-13

1988-07-19

Wiseman, Thomas G.

Chemistry: molecular biology and microbiology

Micro-organism, per se ; compositions thereof; proces of...

Bacteria or actinomycetales; media therefor

435 70, 4351723, 435320, 536 27, 935 13, 935 29, 935 31, 935 72, C12N 120, C12N 1500, C12N 100, C12P 2102, C07H 1700

Patent

active

047585161

ABSTRACT:
Genes and DNA transfer vectors for the expression of human preprorelaxin; sub-units thereof, including genes and transfer vectors for expression of human prorelaxin and the individual A, B and C peptide chains thereof; and equivalents of all such genes. Methods for synthesis of the peptides involving recombinant DNA techniques.

REFERENCES:
patent: 4468464 (1984-08-01), Cohen et al.
Johnston, P. et al. in Peptides, Structure and Function Proc. Ninth Amer. Peptide Symposium, (Ed. Deber, C. et al.) Pierce Chemical Comp., Rockford, Ill. pp. 683-686, 1985.
Blundell, et al. in "Biology of Relaxin and Its Role in the Human" (Bigazzie et al., Eds), Exerpta Medica, Amsterdam, pp. 14-21, 1983.
Dodson et al., Int. J. Biol. Macromol., vol. 4, pp. 399-405, 1982.
Isaacs et al., Nature, vol. 271, pp. 278-281, 1978.
Hudson, P. et al., Nature, vol. 291, pp. 127-131, 1981.
Weiss, G. et al., Science, vol. 194, pp. 948-949, 1976.
Hudson et al., 1983, "Structure of a Genomic Clone Encoding Biologically Active Human Relaxin" Nature vol. 301, pp. 628-631.
Shine et al., 1980, (Abstract) "Approaches to the Cloning of Relaxin Gene Sequences" Chem Abstr, vol. 96 #194404.
James et al., 1977, "Primary Structure of Porcine Relaxin: Homology with Insulin and Related Growth Factors" Nature vol. 267, pp. 544-546.
Suggs et al., 1981, Use of Synthetic Oligonucleotides as Hybridization Probes: Isolation of Cloned CDNA Sequences . . ." PNAS, vol. 78(11) 6613-17.
Maniatis et al., 1982 Molecular Cloning: A Laboratory Manual, Cold Spring Harbor Laboratory, pp. 422 and 427.

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