Molecular biosensors for use in competition assays

Details Molecular biosensors for use in competition assays Molecular biosensors for use in competition assays

2007-08-09

2010-10-12

Forman, B J (Department: 1634)

Chemistry: molecular biology and microbiology

Apparatus

Including measuring or testing

C435S006120, C435S007200, C536S023100, C536S024300

Reexamination Certificate

active

07811809

ABSTRACT:
The invention generally provides molecular biosensors. The molecular biosensors are useful in competition assays to detect the presence of a target molecule.

REFERENCES:
patent: 5270163 (1993-12-01), Gold et al.
patent: 5475096 (1995-12-01), Gold et al.
patent: 5476766 (1995-12-01), Gold et al.
patent: 5543293 (1996-08-01), Gold et al.
patent: 5567588 (1996-10-01), Gold et al.
patent: 5582981 (1996-12-01), Toole et al.
patent: 5637459 (1997-06-01), Burke et al.
patent: 5641629 (1997-06-01), Pitner et al.
patent: 5650275 (1997-07-01), Pitner et al.
patent: 5660985 (1997-08-01), Pieken et al.
patent: 5670637 (1997-09-01), Gold et al.
patent: 5683867 (1997-11-01), Biesecker et al.
patent: 5688935 (1997-11-01), Stephens et al.
patent: 5696249 (1997-12-01), Gold et al.
patent: 5705337 (1998-01-01), Gold et al.
patent: 5712375 (1998-01-01), Jensen et al.
patent: 5723289 (1998-03-01), Eaton et al.
patent: 5723592 (1998-03-01), Eaton et al.
patent: 5750342 (1998-05-01), Stephens et al.
patent: 5756291 (1998-05-01), Griffin et al.
patent: 5763566 (1998-06-01), Jensen et al.
patent: 5763595 (1998-06-01), Gold et al.
patent: 5773598 (1998-06-01), Burke et al.
patent: 5789157 (1998-08-01), Jensen et al.
patent: 5789160 (1998-08-01), Eaton et al.
patent: 5817785 (1998-10-01), Gold et al.
patent: 5840867 (1998-11-01), Toole et al.
patent: 5843653 (1998-12-01), Gold et al.
patent: 5853984 (1998-12-01), Davis et al.
patent: 5858660 (1999-01-01), Eaton et al.
patent: 5861254 (1999-01-01), Schneider et al.
patent: 5864026 (1999-01-01), Jensen et al.
patent: 5874218 (1999-02-01), Drolet et al.
patent: 5958691 (1999-09-01), Pieken et al.
patent: 5962219 (1999-10-01), Gold et al.
patent: 5989823 (1999-11-01), Jayasena et al.
patent: 5998142 (1999-12-01), Gold et al.
patent: 6001570 (1999-12-01), Grossman
patent: 6001577 (1999-12-01), Gold et al.
patent: 6011020 (2000-01-01), Gold et al.
patent: 6013443 (2000-01-01), Heilig et al.
patent: 6030776 (2000-02-01), Eaton et al.
patent: 6048698 (2000-04-01), Eaton et al.
patent: 6083696 (2000-07-01), Biesecker et al.
patent: 6110900 (2000-08-01), Gold et al.
patent: 6114120 (2000-09-01), Jensen et al.
patent: 6127119 (2000-10-01), Stephens et al.
patent: 6147204 (2000-11-01), Gold et al.
patent: 6177555 (2001-01-01), Jayasena et al.
patent: 6207388 (2001-03-01), Grossman
patent: 6225058 (2001-05-01), Munishkin et al.
patent: 6261774 (2001-07-01), Pagratis et al.
patent: 6261783 (2001-07-01), Jayasena et al.
patent: 6291184 (2001-09-01), Gold et al.
patent: 6300074 (2001-10-01), Gold et al.
patent: 6329145 (2001-12-01), Janjic et al.
patent: 6331398 (2001-12-01), Gold et al.
patent: 6344318 (2002-02-01), Gold et al.
patent: 6376190 (2002-04-01), Gold et al.
patent: 6391593 (2002-05-01), Weston
patent: 6399302 (2002-06-01), Lannigan et al.
patent: 6423493 (2002-07-01), Gorenstein et al.
patent: 6451588 (2002-09-01), Egholm
patent: 6465188 (2002-10-01), Gold et al.
patent: 6506887 (2003-01-01), Smith et al.
patent: 6511809 (2003-01-01), Baez
patent: 6544746 (2003-04-01), Heyduk
patent: 6593091 (2003-07-01), Keys et al.
patent: 6613526 (2003-09-01), Heilig et al.
patent: 6680377 (2004-01-01), Stanton et al.
patent: 6716583 (2004-04-01), Gold et al.
patent: 6730482 (2004-05-01), Gold et al.
patent: 6878515 (2005-04-01), Landegren
patent: 6916613 (2005-07-01), Munishkin et al.
patent: 2002/0022224 (2002-02-01), Hornby et al.
patent: 2002/0037506 (2002-03-01), Lin et al.
patent: 2002/0051986 (2002-05-01), Baez
patent: 2003/0087239 (2003-05-01), Stanton et al.
patent: 2003/0207271 (2003-11-01), Holwitt et al.
patent: 2003/0224435 (2003-12-01), Seiwert
patent: 2003/0232388 (2003-12-01), Kreimer et al.
patent: 2004/0053310 (2004-03-01), Shi et al.
patent: 2004/0058378 (2004-03-01), Kong et al.
patent: 2004/0067501 (2004-04-01), Kage
patent: 2004/0180360 (2004-09-01), Wilson et al.
patent: 2004/0219523 (2004-11-01), Stanton et al.
patent: 2005/0069910 (2005-03-01), Turner et al.
patent: 2005/0095627 (2005-05-01), Kolman et al.
patent: 2005/0106594 (2005-05-01), Ellington et al.
patent: 2005/0112710 (2005-05-01), Torres et al.
patent: 2006/0110739 (2006-05-01), Heyduk et al.
patent: 9700446 (1997-01-01), None
patent: WO 03/064657 (2003-08-01), None
patent: WO 03/078449 (2003-09-01), None
patent: WO2005/059509 (2005-06-01), None
TriLink-PEG-282 brochure, Sep. 8, 2009.
SantaLucia, A ubified view of polymer, dumbell, and oligonucleotide DNA nearest neighbor themodynamics,1998, PNAS, 95, 1460-1465.
Bock, L.C., et al., “Selection of single-stranged DNA molecules that bind and inhibit human thrombin”,Nature(1992) pp. 564-566, vol. 355.
Burgstaller, P., et al. , “Synthetic Ribozymes and the First Deoxyribozyme”,Angew. Chem. Int. Ed. Engl. (1995) pp. 1189-1192, vol. 34, No. 11.
Ellington, A.D., et al., “In vitro selection of RNA molecules that bind specific ligands”,Nat. (1990) pp. 818-822, vol. 346.
Famulok, M., et al., “In Vitro Selection of Specific Ligand-binding Nucleic Acids”,Angew. Chem. Int. Ed. Engl. (1992) pp. 979-988, vol. 31.
Fang, et al., “Synthetic DNA Aptamers to Detect Protein Molecular Variants in a High-Throughput Fluorescence Quencing Assay”,ChemBioChem. (2003) pp. 829-834, vol. 4.
Gold, L., et al., “Diversity of Oligonucleotide Functions”,Ann. Rev. Biochem. (1995) pp. 763-797, vol. 64.
Hamaguchi, et al., “Aptamer Beacons for the Direct Detection of Proteins”,Analy. Biochem. (2001) pp. 126-131, vol. 294.
Heyduk, E., et al., “Thiol-reactive, Luminescent Europium Chelates: Luminescence Probes for Resonance Energy Transfer Distance Measurements in Biomolecules”,Anal. Biochem. (1997) pp. 216-227, vol. 248.
Heyduk, E., et al., “Conformational Changes of DNA Induced by Binding ofChironomusHigh Mobility Group Protein 1a (cHMG1a)”,J. Biol. Chem. (1997) pp. 19763-19770, vol. 272, No. 32.
Heyduk, E., et al., “Homogeneous Fluorescence Assay for Cyclic AMP”,Comb. Chem. and High Throughput Screen. (2003) pp. 347-354, vol. 6.
Heyduk, T., et al., “Luminescense Energy Transfer with Lanthanide Chelates: Interprepation of Sensitized Acceptor Decay Amplitudes”,Analy Biochem(2001) pp. 60-67, vol. 289, No. 1.
Heyduk, T., et al., “Molecular beacons for detecting DNA binding proteins”,Nat. Biotech. (2002) pp. 171-176, vol. 20.
Heyduk, E., et al., “Molecular beacons for detecting DNA binding proteins: mechanism of action”,Analyt. Biochem. (2003) pp. 1-10, vol. 316.
Jayasena, S.D., “Aptamers: An Emerging Class of Molecules That Rival Antibodies in Diagnostics”,Clin. J. Chem. (1999) pp. 1628-1650, vol. 45, No. 9.
Klug, S., et al., “All you wanted to know about SELEX (but were afraid to ask . . . )”,Mol. Biol. Rep(1994) pp. 97-107, vol. 20.
Knoll, E., et al., “Unimolecular Beacons for the Detection of DNA-Binding Proteins”,Anal. Chem. (2004) pp. 1156-1164, vol. 76, No. 4.
Li, J.J., et al., “Molecular Aptamer Beacons for Real-Time Protein Recognition”,Biochem. and Biophys. Res. Commun. (2002) pp. 31-40, vol. 292, No. 1.
Mathis, G., “Probing Molecular Interactions with Homogeneous Techniques Based on Rare Earth Cryptrates and Fluorescence Energy Transfer”, Clinic. Chem. (1995) pp. 1391-1317, vol. 41, No. 9.
Matlock, D.L., et al., “Sequence Determinants for the Recognition of the Fork Junction DNA Containing the—10 Region of Promoter DNA byE. coliRNA Polymerase”,Biochem. (2000) pp. 12274-12283, vol. 39, No. 40.
Mills, J.B., et al., “Flexibility of Single-Stranged DNA: Use of Gapped Duplex Helices to Determine the Persistence Lengths of Poly(dT) and Poly(dA)”,J. Mol. Biol. (1999) pp. 245-257, vol. 285.
Selvin, P.R., et al., “Luminescence Resonance Energy Transfer”,J. Am. Chem. Soc. (1994) pp. 6029-6030, vol. 116.
Selvin, P.R., et al., “Luminescence energy transfer using a terbium chelate: Improvements on fluorescence energy transfer”,Proc. Natl. Acad. Sci USA(1994) pp. 10024-

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