Molecular beacons, methods and kits for detecting DNA damage...

Details Molecular beacons, methods and kits for detecting DNA damage... Molecular beacons, methods and kits for detecting DNA damage...

2006-09-01

2009-06-30

Benzion, Gary (Department: 1637)

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

C435S091200

Reexamination Certificate

active

07553955

ABSTRACT:
This invention relates to embodiment to a molecular beacon, methods and kits for the detection of expression of p21(Waf1/Cip1), in response to chemotherapy. Specifically, the introduction of a phosphorothioate-modified p21-beacon by transfection in human tumor cells yields increased signal in a dose dependent manner.

REFERENCES:
patent: 6083695 (2000-07-01), Hardin et al.
Tsourkas et al. Nucleic acids Research, vol. 30, No. 23, pp. 5168-5174, 2002.
Kreeger, Karen., University of Pennsylvania, Abramson Cancer Center News, pp. 1-4, Nov. 30, 2004 (http://www.penncancer.com/penn—news.cfm).

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