Molecular basis of the human platelet bra/brb alloantigen system

Details Molecular basis of the human platelet bra/brb alloantigen system Molecular basis of the human platelet bra/brb alloantigen system

1993-06-30

1996-05-14

Jones, W. Gary

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

435 912, 435 915, 435199, 536 235, 536 2431, 536 2433, 935 8, 935 17, 935 77, 935 78, C12Q 168, C12P 1934, C07H 2104

Patent

active

055166342

ABSTRACT:
Based on the discovery of the amino acid and nucleotide differences which distinguish the Br.sup.a and Br.sup.b allelic forms of the membrane glycoprotein GPIa, and which comprise the diallelic Br platelet alloantigen system, compositions and methods are provided for determining the Br genotype and phenotype of individuals. Also provided, on the basis of this discovery, are compositions and methods for treating disorders associated with Br alloantigen incompatibility, such as the bleeding disorders post-transfusion purpura, post-transfusion platelet refractoriness, and neonatal alloimmune thrombocytopenic purpura. The two allelic forms of GPIa differ by a single amino acid. The Br.sup.a allelic form has Lys at position 505 in the sequence of the mature GPIa. The Br.sup.b allelic form has Glu at the same position. This amino acid difference is due to a single change, from A for the Br.sup.a allele to G for the Br.sup.b allele, in the GPIa gene.

REFERENCES:
Bochringer Mannhein Catalog, p.144, 1990/1991.
Santoso et al, Tissue Antigens (1989) 33(2):358.
Takada et al, J. Cell Biology (1989) 109:397-407.

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