Molecular activation for tandem mass spectroscopy

Details Molecular activation for tandem mass spectroscopy Molecular activation for tandem mass spectroscopy

2008-06-10

2008-06-10

Berman, Jack I. (Department: 2881)

Radiant energy

Ionic separation or analysis

C250S288000, C250S282000, C250S285000, C250S492300, C250S442110, C250S292000, C250S400000, C435S006120, C435S015000, C435S014000, C435S018000, C435S105000, C436S093000, C436S086000, C436S094000, C436S173000

Reexamination Certificate

active

07385185

ABSTRACT:
In a tandem mass spectrometer means are provided for molecular activation of ions prior to fragmentation. An embodiment of a tandem mass spectrometer comprises a first collision cell receiving analyte ions having an internal energy and a second collision cell situated downstream from the first collision cell wherein the first collision cell increases the internal energy of the analyte ions prior to entry of the ions into the second collision cell, the increase in internal energy imparted in the first collision cell alone being insufficient to fragment a substantial portion of the analyte ions. Another embodiment includes a collision cell with a heating device situated adjacent to the collision cell for controlling the temperature within the collision cell.

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UK Search Report for Application No. GB0625305.8, mailed Jul. 10, 2007, corresponding to U.S. Appl. No. 11/314,592, 1 page.
Sleno et al., “Ion Activation Methods for Tandem Mass Spectrometry”, (2004), Journal of Mass Spectrometry vol. 39, pp. 1091-1112.
S. McLuckey et al., “Slow Heating Methods in Tandem Mass Spectrometry”, (1997), Journal of Mass Spectrometry vol. 32, pp. 461-474.
V. Gabelica et al., “Internal Energy and Fragmentation of Ions Produced in Electrospray Sources”, (2004), Published in Mass Spectrometry Reviews vol. 24, pp. 566-587.

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