Molded, storage stable suppository base composition of specified

Details Molded, storage stable suppository base composition of specified Molded, storage stable suppository base composition of specified

1980-10-20

1983-01-11

Rose, Shep K.

Drug, bio-affecting and body treating compositions

Solid synthetic organic polymer as designated organic active...

Polymer from ethylenic monomers only

424365, 424DIG15, A61K 902, A61K 31765, A61K 3175, A61K 4700

Patent

active

043681859

ABSTRACT:
A suppository base composition comprising 5-80% by weight of polyethylene glycol, 5-80% by weight of triglyceride of fatty acid having 6-22 carbon atoms and 5-80% by weight of a specifically limited alkylene oxide derivative has a melting point of 30.degree.-60.degree. C., a compatibility with both of a polar drug component and a non-polar drug component, and can provide suppositories having excellent moldability and storage stability.

REFERENCES:
patent: 2538127 (1951-01-01), Saunders et al.
patent: 2975099 (1961-03-01), Goyan et al.
patent: 3767801 (1973-10-01), Tuma et al.
Chem. Abstracts 92 #220693t (1980) of Jpn. Kokai Tokkyo Koho 79157820.
Lachman et al., The Theory & Practice of Industrial Pharmacy, 2nd Ed. (1976), Lea and Febiger, Phila., Pa., "Suppositories", pp. 245-269, Semi-Solids, pp. 215-244, Emulsions, pp. 184-214.

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