Moisturizer

Details Moisturizer Moisturizer

1994-09-22

1997-07-01

Venkat, Jyothsna

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Cosmetic, antiperspirant, dentifrice

424427, 424430, 424434, 424436, 514938, A61K 748

Patent

active

056435827

DESCRIPTION:

BRIEF SUMMARY
FIELD OF THE INVENTION

This invention is a moisturizer for rehydrating or maintaining hydration in skin and mucous membranes using bioadhesives in combination with humectants and water complexing agents. In addition this moisturizer has lubricating properties derived from the moisturizing properties and unctuous components which make it useful in preventing abrasions or soreness and redness resulting from contact with other materials.
Moisturizers are widely available for treating topical skin problems like dry, flaking or cracked skin caused by loss of water, or abrasions and redness caused by exposure and rubbing. The consumer has many choices. But as a general rule skin lotions and skin conditioners fail into a limited group of types of formulations which can be broken out into two main categories, the oil-in-water emulsions and hydrophobic barriers illustrated by the likes of petrolatum. Many of these formulations can be used on either dermal or mucosal tissue and will work well on both types of tissue, at least on the short or very short term of a few hours or so.
Nearly all these products work by preventing or reducing moisture loss rather than adding moisture back to the skin. Petrolatum and similar products are among the best at preventing or reducing water loss, and since petrolatum adheres well to the skin, it's residence time and its affect is extended. The major draw-back to its use is that user acceptance is low because it is viewed as messy and unsightly; it does not absorb well into the skin and the skin has what is viewed a peculiar feel. Oil-in-water emulsions are usually more user acceptable as they are absorbed into the skin. but often they lack a sustainable affect; water evaporation from the formula, once applied to the skin is high, the barrier properties are relative low, and the formulation does not remain on the skin in a useful form for very long.
Attempts have been made to develop formulations which can replenish the water lost through normal evaporation. Some compounds such as glycerol and some amino acids like arginine have found some favor in these attempts and have been labeled humectants. Along with work on humectants, xerogels have been used in an attempt to increase the residence time on the skin of the water in the moisturizers. Some of these formulations may have lubricating properties as well, though this is not well documented. Two examples of interest in the context of one use of this invention is Lubrin sold by Upsher-Smith Labs Inc., a suppository for treating vaginal dryness and Replens marketed by Columbia Labs, Miami, Fla.
Unlike other moisturizers the one described here has both a short acting and a long acting component and the capability to adhere to and remain adhered to the site for up to several days. This is due to the use of two adhesive agents. One is immediately available when the moisturizer is applied. The other becomes available at a later time as the gust adhesive agent is being dissolved or eroded away. A composite particulate is used to provide both adhesives.


SUMMARY OF THE INVENTION

This invention has at least three aspects. One is a moisturizing cream per Se. A second embodiment is a method of producing this cream by combining two compositions at about the time of using the moisturizer. And the third is an article of manufacture where the two components are presented in separate vessels for combining in anticipation of immediate use.
More specifically, in a first aspect, this invention relates to a moisturizer for epithelial cells comprising a mixture of purified water, a water soluble polymer having bioadhesive properties, one or more preservatives, a humectant, a pharmaceutically acceptable oil, glycerides and bilayer polymeric particles comprising a hydrophobic adhesive polymer core coated with a water soluble, hydrophilic bioadhesive polymer.
In a second aspect, this invention relates to a moisturizing product, preferably a cream, for application to epithelial cells prepared by mixing two compositions from separate sources at about the

REFERENCES:
patent: 4032628 (1977-06-01), Papantoniou et al.
patent: 4300820 (1981-11-01), Shah
patent: 4347237 (1982-08-01), Evenstad et al.
patent: 5004598 (1991-04-01), Lochhead et al.
patent: 5066709 (1991-11-01), Chaudhuri et al.

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