Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2005-01-13
2009-12-01
Aulakh, Charanjit S (Department: 1625)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C546S074000, C546S063000, C514S286000
Reexamination Certificate
active
07625921
ABSTRACT:
A class of novel non-steroidal compounds are provided which are useful in treating diseases associated with modulation of the glucocorticoid receptor, AP-1, and/or NF-κB activity including obesity, diabetes, inflammatory and immune diseases, and have the structure of formula (I)its stereoisomers thereof, or a solvate thereof, or a prodrug thereof, or a pharmaceutically acceptable salt thereof, where Z is CONR1R2or CH2NR1R2and where at least one of X1-X8is N, and R, Ra, Rb, Rcand Rdare defined herein. Also provided are pharmaceutical compositions and methods of treating obesity, diabetes and inflammatory or immune associated diseases comprising said compounds.
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Duan Jingwu
Gilmore John L.
Jiang Bin
Sheppeck James
Aulakh Charanjit S
Bristol--Myers Squibb Company
Duncan Laurelee A.
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