Modulators of serotonin receptors

Details Modulators of serotonin receptors Modulators of serotonin receptors

2007-07-17

2007-07-17

Tucker, Zachary C (Department: 1624)

Organic compounds -- part of the class 532-570 series

Organic compounds

Unsubstituted hydrocarbyl chain between the ring and the -c-...

C540S495000, C540S545000, C540S557000, C544S009000, C544S344000

Reexamination Certificate

active

10958325

ABSTRACT:
The present invention provides modulators of serotonin receptors, pharmaceutical compositions containing such modulators and methods for treating various diseases, conditions and disorders associated with modulation of serotonin receptors such as, for example: metabolic diseases, which includes but is not limited to obesity, diabetes, diabetic complications, atherosclerosis, impared glucose tolerance and dyslipidemia; central nervous system diseases which includes but is not limited to, anxiety, depression, obsessive compulsive disorder, panic disorder, psychosis, schizophrenia, sleep disorder, sexual disorder and social phobias; cephalic pain; migraine; and gastrointestinal disorders using such compounds and compositions.

REFERENCES:
patent: 3517012 (1970-06-01), Regnier et al.
patent: 4273773 (1981-06-01), Demerson et al.
patent: 5028607 (1991-07-01), Lavielle et al.
patent: 5929085 (1999-07-01), MacDonald et al.
patent: WO 99/42456 (1999-08-01), None
patent: WO 02/059127 (2002-08-01), None
patent: WO 03/076440 (2003-09-01), None
Database Caplus ′Online! Chemical Abstracts Service, Columbus, Ohio, US; May 12, 1984, XP002316369, retrieved from STN, Database Accession No. 1973:537088 abstract.
Database Caplus ′Online! Chemical Abstracts Service, Columbus, Ohio, US; Jul. 27, 1985, XP002316399, retrieved from STN, Database Accession No. 1985:422553 abstract.
Database Caplus ′Online! Chemical Abstracts Service, Columbus, Ohio, US; May 12, 1984, XP002316400, retrieved from STN, Database Accession No. 1975:531546 abstract.
Database Caplus ′Online! Chemical Abstracts Service, Columbus, Ohio, US; May 12, 1984, XP002316401, retrieved from STN, Database Accession No. 1977:468283 abstract.
Ferland, J.-M. et al., “Synthesis of derivatives of isoindole and pyrazino[2,1-α]isoindole”, Can. J. Chem., vol. 63, pp. 361-365 (1985).
Kato, H. et al., “Studies on 1-Azabicyclo Compounds. XV. Oxidation of 1,3,4,6,11,11a-Hexahydro-2H-pyrazino[1,2-b]isoquinolin-1-one Derivatives with Mercuric Acetate, and Their Conversion into 1,2,3,4,5,6,7,8-Octahydro-2-methyl-2,5-benzodiazecine and Related Compounds”, Chem. Pharm. Bull., vol. 21, No. 9, pp. 2039-2047 (1973).
Rao, J. et al., “Synthesis of N-[3-Aryl(thio/sulphono)propyl]heterocyclics as Potential CNS/CVS Agents”, Indian Journal of Chemistry, vol. 26B, pp. 761-765 (1987).
Saxena, A.K. et al., “Compounds Acting on the CNS: Part XXI—Synthesis of 2-Substituted 1,3,4,6,11,11a-Hexahydro-2(H)pyrazino[1,2-b]isoquinoline & Corresponding 8,9-Dimethoxy- & 6-Phenyl-8,9-dimethoxy Analogs”, Indian Journal of Chemistry, vol. 13, pp. 230-237 (1975).
Saxena, M. et al., “Synthesis, Biological Evaluation, and Quantitative Structure-Activity Relationship Analysis of [β-(Aroylamino)ethyl]piperazines and -piperidines and [2-[(Arylamino)carbonyl]ethyl]piperazines, -piperidines,—pyrazinopyridoindoles, and -pyrazinoisoquinolines. A New Class of Potent H1Antagonists”, J. Med. Chem., vol. 33, No. 11, pp. 2970-2976 (1990).
Singh, H. et al., “Studies in Potential Filaricides: Part X—Synthesis of 2-Substituted 1,3,4,6,11,11a-Hexahydro-2H-pyrazino[1,2-b]isoquinolin-6-ones”, Indian Journal of Chemistry, vol. 15B, pp. 70-72 (1977).
Sullivan, H.B. et al., “Synthesis of 1,3,4,6,11,11a-Hexahydro-2H-pyrazino[1,2-b]isoquinoline and Perhydro-1H-pyrazino[1,2-a]quinoline”, Journal of Organic Chemistry, vol. 29, pp. 326-328 (1964).
Welch, W.M., “Synthesis of the 1,2,3,4-Tetrahydropyrazino[2,1-a]isoindol-6(2H)-one Ring System”, J. Org. Chem., vol. 47, No. 5, pp. 886-888 (1982).

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