Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...
Patent
1998-12-11
2000-11-21
McKane, Joseph K.
Organic compounds -- part of the class 532-570 series
Organic compounds
Heterocyclic carbon compounds containing a hetero ring...
548127, 548128, 548131, 548134, 548136, 548146, 548206, 548236, 548250, 548255, 5482662, 5483351, 5483601, 5483731, 548440, 548469, 548492, 548518, 549 60, 549 70, 549 71, 549 72, 549414, 549425, 549426, 549429, 549430, 549434, 549462, 549483, 549484, 549491, 549398, 546152, 546167, 5462714, 544 63, 544 83, 544 88, 544 96, 544180, 544238, 544242, 544264, 544269, 544283, 544284, 544353, C07D26334, C07D26344, C07D26348, C07D41304
Patent
active
061505323
ABSTRACT:
The present invention relates to novel protein tyrosine phosphatase modulating compounds having the general structure shown in Formula (A1), to methods for their preparation, to compositions comprising the compounds, to their use for treatment of human and animal disorders, to their use for purification of proteins or glycoproteins, and to their use in diagnosis. The invention relates to modulation of the activity of molecules with phosphotyrosine recognition units, including protein tyrosine phosphatases (PTPases) and proteins with Src-homology-2 domains, in in vitro systems, microorganism, eukaryoic cells, whole animals and human being. R' and R" are independently selected from the group consisting of hydrogen, halo, cyano, nitro, trihalomethyl, alkyl, arylalkyl. R'" is selected from the group consisting of hydrogen, alkyl, substituted alkyl, aryl, arylalkyl. X is aryl. Y is selected from hydrogen or ##STR1## wherein (*) indicates a potential point of attachment to X.
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Bakir Farid
Cao Xiaodong
Mjalli Adnan
Sarshar Sepehr
Chow Frank S.
McKane Joseph K.
Oswecki Jane C.
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