Modulators of odorant receptors

Details Modulators of odorant receptors Modulators of odorant receptors

2008-10-30

2010-11-23

Ulm, John D (Department: 1649)

Chemistry: molecular biology and microbiology

Animal cell, per se ; composition thereof; process of...

C435S007200, C435S069100, C435S361000

Reexamination Certificate

active

07838288

ABSTRACT:
The present invention relates to polypeptides capable of promoting odorant receptor cell surface localization and odorant receptor functional expression. The present invention further provides assays for the detection of ligands specific for various odorant receptors. Additionally, the present invention provides methods of screening for odorant receptor accessory protein polymorphisms and mutations associated with disease states, as well as methods of screening for therapeutic agents, ligands, and modulators of such proteins.

REFERENCES:
patent: 5993778 (1999-11-01), Firestein
patent: 2002/0048812 (2002-04-01), Ronnett
patent: 2005/0233418 (2005-10-01), Baum
patent: 01/75067 (2001-10-01), None
patent: 03/025130 (2003-03-01), None
patent: WO 03/098221 (2003-11-01), None
Gomez et al. Induction of Differentiation of Human Olfactory Neuroblastoma Cells into Odorant-responsive Cells, 1996, Neuroscience vol. 74, No. 2, pp. 567-577.
Adler et al. (2000), “A Novel Family of Mammalian Taste Receptors,” Cell 100,693-702.
Angers, S., et al. (2002), “Dimerization: An Emerging Concept for G Protein-Coupled Receptor Ontogeny and Function,” Annu Rev Pharmacol Toxicol 42,409-435.
Axel R., (1995), “The Molecular Logic of Smell . . . ”, Sci Am 1273, 154-159.
Baker, E.K., et al. (1994), “The Cyclophilini homolog NinaA functions as a chaperone, forming a stable complex in vivo with its protein target rhodopsin,” Embo J 13,4886-4895.
Belluscio, L., et al. (1998), “Mice Deficient in Golf Are Anosmic,” Neuron 20,69-81.
Bozza T., et al., “Odorant Receptor Expression Defines Functional Units in the Mouse Olfactory System,” (2002) J Neurosci 22,3033-3043.
Brady, A.E and Limbird, L.E. (2002), “G protein-coupled receptor interacting proteins: Emerging roles in localization and signal transduction,” Cell Signal 14,297-309.
Brady, G., and Iscove, N. N. (1993), “Construction of cDNA Libraries from Single Cells,” Methods Enzymol 225,611-623.
Brands, A., and Ho, T.H. (2002), “Function of a Plant Stress-Induced Gene, HVA22. Synthetic Enhancement Screen with Its Yeast Homolog Reveals Its Role in Vesicular Traffic,” Plant Physiol 130,1121-1131.
Buck L, and Axel R. (1991), “A Novel Multigene Family May Encode Odorant Receptors: A Molecular Basis for Odor Recognition,” Cell 65, 175-187.
Calero, M, (2001), “Yop1p, the Yeaste Homolog of the Polyposis Locus Protein 1, Interacts with Yip1p and Negatively Regulates Cell Growth,” J Biol Chem 276,12100-12112.
Chandrashekar, J., et al (2000), “T2Rs Function as Bitter Taste Receptors,” Cell 100,703-711.
Chen, C.N., et al. (2002), “AtHVA22 gene family in Arabibopsis: phylogenetic relationship, ABA and stress regulation, and tissue-specific expression,” Plant Mol Biol 49,633-644.
Database UniProt (online) Jun. 1, 2003, “Receptor-transporting protein 2.” XP002471384 retrieved from EBI accession No. UniProt:Q80Z1s.
Database UniProt (online) Mar. 1, 2001, “Receptor expression-enhancing protein 1.” XP002471382 retrieved from EBI accession No. UniProt:Q9H902.
Database UniProt (online) Mar. 1, 2003, “Receptor expression-enhancing protein 1,” XP002471381, retrieved from EBI accession No. Unipot:Q8BGH4.
Database UniProt (online) Mar. 1, 2003, “Receptor-transporting protein 1.” XP002471383 retrieved from EBI accession No. Uniprot: Q8C8C1, Database accession No. Q8C8C1.
Dulac, C., and Axel R. (1995), “A Novel Family of Genes Encoding Putative Pheromone Receptors in Mammals,” Cell 83,195-206.
Dwyer, N.D., et al. (1998), “Odorant Receptor Localization to Olfactory Cilia is Mediated by ODR-4, a Novel Membrane-Associated Protein,” Cell 93,445-466.
Dwyer, N.D., et al., (2001), “Polarized Dendritic Transport and the AP-1 μ1 Clathrin Adaptor UNC-101 Localize Odorant Receptors to Olfactory Cilia,” Neuron 31, 277-287.
Evans et al., “An engineered poliovirus chimaera elecits broadly reactive HIV-1 neturalizing antibodies,” Nature 339:385 (1989).
Ferreira, P.A., et al., (1996), “Cyclophilin-related protein RanBP2 acts as chaperone for red/green opsin,” Nature 383,637-640.
Firestein, S. (2001), “How the olfactory system makes sense of scents,” Nature 413, 211-218.
Gaillard, I., et al., (2002), “A single olfactory receptor specifically binds a set of odorant molecules,” Eur Neurosci 15,409-418.
Gimelbrant, A. A., et al., (2001), “Olfactory Receptor Trafficking Involves Conserved Regulatory Steps,” J Biol Chem 276,7285-7290.
Glusman, G., et al. (2001), “The Complete Human Olfactory Subgnome,” Genome Res 11,685-702.
Griff, I.C. , and Reed, R.R. (1995), “The Genetic Basis for Specific Anosmia to Isovaleric Acid in the Mouse,” Cell 83,407-414.
Hatt, H. et al., “Cloning, Functional Expression and Characterization of a Human Olfactory Receptor,” (1999) Cell Mol Biol 45,285-291.
Huang et al., “Vaccinia Virus Recombinants Expressing an 11-Kilodalton β-Galactosidase Fusion Protein Incorporate Active β-Galactosidase in Virus Particles,” J. Virol., 62:3855 (1988).
Hurt, C.M. et al. (2000), “Cell-type Specific Targeting of the α2c-Adrenoceptor,” J Biol Chem 275,35424-35431.
International Search Report dated Apr. 10, 2007 for PCT/US2005/021921 (W02006/002161).
Jones, D.T., and Reed, R.R. (1989), “Golf: An Olfactory Neuron Specific-G Protein Involved in Odorant Signal Transduction,” Science 244,790-795.
Jones, K.A., et al. (1998), “GABAβ receptors function as a heteromeric assembly of the subunits GABAβR1 and GABAβR2,” Nature 396,674-679.
Kajiya, K. et al., (2001), “Molecular Bases of Odor Discrimination: Reconstitution of Olfactory Receptors that Recognize Overlapping Sets of Odorants,” J Neurosci 21,6018-6025.
Katada et al., “Odorant Response Assays for a Heterologously Expressed Olfactory Receptor,” Biochemical and Biophysical Research Communications, Jun. 13, 2003, vol. 305, No. 4, pp. 964-969.
Kaupmann, K., et al. (1998), “GABAβ-receptor subtypes assemble into functional heteromeric complexes,” Nature 396, 683-687.
Kinzler, K.W., et al. (1991), “Identification of FAP Locus Genese from Chromosome 5q21,” Science 253,661-665.
Krautwurst D., et al., (1998), “Identification of Ligands for Olfactory Receptors by Functional Expression of a Receptor Library,” Cell 95, 917-926.
Laird, D.W., and Molday, R.S. (1988), “Evidence Against the Role of Phodopsin in Rod Outer Segment Binding to RPE Cells,” Invest Opthalmol Vis Sci 29,419-428.
Lewcock, J.W., and Reed, R. R. (2004), “A Feedback Mechanism Regulates Monoallelic Odorant Receptor Expression,” Proc Natl Acad Sci USA.
Loconto, J., et al., (2003), “Functional Expression of Murine V2R Pheromone Receptors Involves Selective Association . . . ”, Cell 112,607-618.
Lu, M., et al., (2003), “Endoplasmic Reticulum Retention, Degradation, and . . . ”, Traffic 4,416-433.
Malnic, B. et al., (1999), “Combinatorial Receptor Codes for Odors,” Cell 96, 713-723.
Matsunami, H., and Buck, L.B. (1997), “A Multigene Family Encoding a Diverse Array of Putative Pheromone Receptors in Mammals,” Cell 90,755-784.
Matsunami, H., et al. (2000), “A family of candidate taste receptors in human and mouse,” Nature 404,601-604.
McClintock, T.S., (1997), “Functional expression of olfactory-adrenergic receptor . . . ”, Brain Res Mol Brain Res 48,270-278.
McClintock, T.S., and Sammeta, N. (2003), “Trafficking prerogatives of olfactory receptors,” Neuroreport 14,1547-1552.
McLatchie, L.M. et al., (1998), “RAMPs regulate the transport and ligand specificity of the calcitonin-receptor-like receptor,” Nature 393

Affiliated with

Also associated with

Rating

Modulators of odorant receptors does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Modulators of odorant receptors, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Modulators of odorant receptors will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-4247840