Modulators of ob gene and screening methods therefor

Details Modulators of ob gene and screening methods therefor Modulators of ob gene and screening methods therefor

1996-03-19

2000-05-30

Yucel, Remy

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

435 4, 4353201, 536 241, 536 231, 536 235, C12Q 168

Patent

active

060689765

ABSTRACT:
This invention relates to the isolation and cloning of the promoter and other control regions of a human ob gene. It provides a method for identifying and screening for agents useful for the treatment of diseases and pathological conditions affected by the level of expression of an ob gene. These agents interact directly or indirectly with the promoter or other control regions of the ob gene. A PPAR.gamma. agonist, BRL49653, has been identified to be useful in treating anorexia, cachexia, and other diseases characterized by insufficient food intake or body weight loss. Modulators of ob gene expression may be used to treat other diseases such as obesity, diabetes, hypertension, cardiovascular diseases and infertility.

REFERENCES:
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P. Tontonoz, et al., mPPAR.gamma.2: tissue-specific regulator of an adipocyte enhancer, 1994, Genes & Development, vol. 8, pp. 1224-1234.
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Gong, et al. J. Biol. Chem. 271(8):3971-3974 (1996).
Isse, et al. J. Biol. Chem. 270(46):27728-27733 (1995).
Saladin, et al. Nature 377(6549):527-529 (1995).

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