Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Reexamination Certificate
2006-01-12
2008-05-20
Mondesi, Robert (Department: 1656)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
C514S008100, C530S300000, C424S185100, C424S190100
Reexamination Certificate
active
07375086
ABSTRACT:
The present invention relates to intracellular signaling molecules, in particular the Nod2 protein and nucleic acids encoding the Nod2 protein. The present invention provides methods of identifying modulators of Nod2 signaling. In particular, the present invention additionally provides methods of screening immune modulators such as adjuvants using Nod2. The present invention further provides methods of altering Nod2 signaling.
REFERENCES:
patent: 4496778 (1985-01-01), Myers et al.
patent: 4650764 (1987-03-01), Temin et al.
patent: 4657760 (1987-04-01), Kung et al.
patent: 4683195 (1987-07-01), Mullis et al.
patent: 4683202 (1987-07-01), Mullis
patent: 4797368 (1989-01-01), Carter et al.
patent: 4861719 (1989-08-01), Miller
patent: 4873191 (1989-10-01), Wagner et al.
patent: 4940838 (1990-07-01), Schilperoort et al.
patent: 4946787 (1990-08-01), Eppstein et al.
patent: 4965188 (1990-10-01), Mullis et al.
patent: 4980289 (1990-12-01), Temin et al.
patent: 5096815 (1992-03-01), Ladner et al.
patent: 5124263 (1992-06-01), Temin et al.
patent: 5139941 (1992-08-01), Myzyczka et al.
patent: 5173410 (1992-12-01), Ahlquist
patent: 5198346 (1993-03-01), Ladner et al.
patent: 5206344 (1993-04-01), Katre et al.
patent: 5223409 (1993-06-01), Ladner et al.
patent: 5225212 (1993-07-01), Martin et al.
patent: 5399346 (1995-03-01), Anderson et al.
patent: 5459127 (1995-10-01), Felgner et al.
patent: 5474796 (1995-12-01), Brennan
patent: 5500360 (1996-03-01), Ahlquist et al.
patent: 5501967 (1996-03-01), Offringa et al.
patent: 5538848 (1996-07-01), Livak et al.
patent: 5580859 (1996-12-01), Felgner et al.
patent: 5584807 (1996-12-01), McCabe
patent: 5589466 (1996-12-01), Felgner et al.
patent: 5589616 (1996-12-01), Hoffman
patent: 5605798 (1997-02-01), Koster
patent: 5608153 (1997-03-01), Ueyanagi
patent: 5614396 (1997-03-01), Bradley et al.
patent: 5618682 (1997-04-01), Scheirer
patent: 5674713 (1997-10-01), McElroy et al.
patent: 5733731 (1998-03-01), Schatz et al.
patent: 5777324 (1998-07-01), Hillenkamp
patent: 5811238 (1998-09-01), Stemmer et al.
patent: 5824877 (1998-10-01), Hinchee et al.
patent: 5830721 (1998-11-01), Stemmer et al.
patent: 5837458 (1998-11-01), Minshull et al.
patent: 5843654 (1998-12-01), Heisler et al.
patent: 5843669 (1998-12-01), Kaiser et al.
patent: 5846717 (1998-12-01), Brow et al.
patent: 5846795 (1998-12-01), Ahlquist et al.
patent: 5858659 (1999-01-01), Sapolsky et al.
patent: 5866785 (1999-02-01), Donson et al.
patent: 5888780 (1999-03-01), Dahlberg et al.
patent: 5891840 (1999-04-01), Cady et al.
patent: 5919626 (1999-07-01), Shi et al.
patent: 5925525 (1999-07-01), Fodor et al.
patent: 5952174 (1999-09-01), Nikiforov et al.
patent: 5965794 (1999-10-01), Turpen
patent: 5976796 (1999-11-01), Szalay et al.
patent: 5977438 (1999-11-01), Turpen et al.
patent: 5981839 (1999-11-01), Knauf et al.
patent: 5985551 (1999-11-01), Brennan
patent: 5985557 (1999-11-01), Prudent et al.
patent: 5994069 (1999-11-01), Hall et al.
patent: 6001311 (1999-12-01), Brennan
patent: 6001567 (1999-12-01), Brow et al.
patent: 6017696 (2000-01-01), Heller
patent: 6043031 (2000-03-01), Koster et al.
patent: 6045996 (2000-04-01), Cronin et al.
patent: 6051380 (2000-04-01), Sosnowski et al.
patent: 6051757 (2000-04-01), Barton et al.
patent: 6063947 (2000-05-01), DeBonte et al.
patent: 6068818 (2000-05-01), Ackley et al.
patent: 6074859 (2000-06-01), Hirokawa et al.
patent: 6080912 (2000-06-01), Bremel et al.
patent: 6090543 (2000-07-01), Prudent et al.
patent: 0 025 949 (1980-09-01), None
patent: 078 220 (1985-10-01), None
patent: 0 185 573 (1985-11-01), None
patent: 0 453 242 (1991-04-01), None
patent: 0 488 528 (1991-10-01), None
patent: WO 93/03367 (1983-02-01), None
patent: WO 84/03564 (1984-09-01), None
patent: WO 90/08832 (1990-08-01), None
patent: WO 91/18088 (1991-11-01), None
patent: WO 92/05263 (1992-04-01), None
patent: WO 94/12649 (1994-06-01), None
patent: WO 94/21807 (1994-09-01), None
patent: WO 94/26914 (1994-11-01), None
patent: WO 94/28152 (1994-12-01), None
patent: WO 94/28938 (1994-12-01), None
patent: WO 95/02697 (1995-01-01), None
patent: WO 95/21931 (1995-08-01), None
patent: WO 96/25508 (1996-08-01), None
patent: WO 99/67641 (1999-12-01), None
patent: WO 00/39587 (2000-07-01), None
Chou et al., Cell, 94:171 [1991].
Takeuchi et al., Immunity, 4:443 [1999].
Bertin et al., J. Biol. Chem. 274:12955-12958 [1999].
Li et al., Cell 91:479-489 [1997].
Zou et al., J. Biol. Chem. 274:11549-11556 [1999].
Snivasula et al., Mol. Cell 1:949-957 [1998].
Hu et al., J. Bio. Chem. 273: 33489-34494 [1998].
Inohara et al., J. Biol. Chem. 273:12296-12300 [1998].
McCarthy et al., J. Bio. Chem. 273:16968-16975 [1998].
Thome et al., Curr. Biol. 8:885-888 [1998].
Inohara et al., J. Biol. Chem. 275:27823-27831 [2000].
Parniske et al., Cell 91:821-832 [1997].
Yang et al., Nature, 395:284-288 [1998].
Aliprantis et al., Science, 285:736-739 [1999].
Poltorak et al., Science, 282:2085-2088 [1998].
Zou et al., Cell, 90:405-413 [1997].
Inohara et al., J. Biol. Chem., 274:14560-14568 [1999].
Shimada et al., Int. Immunol., 11:1357-1362 [1999].
Huang et al., PNAS, 94:12829-12832 [1997].
Medzhitov et al., Mol. Cell, 2:253-258 [1998].
Hsu et al., Immunity, 4:387-396 [1996].
Yamaoka et al., Cell 93: 1231-1240 [1998].
Kobe and Deisenhofer, Curr. Opin. Struct. Biol. 5: 409-416 [1995].
Hu et al., EMBO J. 18: 3586-3595 [1991].
Karin, J. Biol. Chem. 274: 27339-27342 [1999].
Hofmann et al., Trends Biochem. Sci. 22: 155-156 [1997].
MacCorkle et al., Proc. Nat. Acad. Sci. U. S. A. 95: 3655-3660 [1998].
Schwandner et al., J. Biol. chem., 274:17406-17409 [1999].
Aderem and Ulevitch, Nature, 406:782-787 [2000].
Philpott et al., J. Immunol., 165:903-914 [2000].
Chow et al., J. Biol. Chem., 274:10689-10692 [1999].
Anderson and Young, Quantitative Filter Hybridization,in Nucleic Acid Hybridization[1985].
Smith and Waterman, Adv. Appl. Math. 2: 482 [1981].
Needleman and Wunsch, J. Mol. Biol. 48:443 [1970].
Pearson and Lipman, Proc., Natl. Acad. Sci. (U.S.A.) 85:2444 [1988].
Chamberlin et al., Nature 228:227 [1970].
H.A. Erlich (ed.),PCR Technology, Stockton Press [1989].
J. Sambrook et al.,Molecular Cloning: A Laboratory Manual, Cold Spring Harbor Press, NY, pp. 9.31-9.58 [1989].
Graham and van der Eb, Virol., 52;456 [1973].
Neer, 1995. Cell 80:249-257 [1995].
Stermweis and Smrcka, Trends in Biochem. Sci. 17:502-506 [1992.
Carbounneau, H. and Tonks, Annu. Rev. Cell Biol. 8:463-93 [1992].
Saito et al., Cell Growth and Diff. 2:59-65 [1991].
DeWet et al., Mol. Cell. Biol. 7:725 [1987].
Wahl, et al., Meth. Enzymol., 152:399-407 [1987].
Sudarickov et al., Nucleic Acids Res., 16:8187 [(1988].
Parker et al., Nucleic Acids Res., 19:3055-60 [1991].
Stryer ed.,Biochemistry, p. 17-21, 2nd ed. WH Freeman and Co., [1981].
Murray et al., Nucl. Acids Res., 17 [1989].
Gluzman, Cell 23:175 [1981].
Davis et al., Basic Methods in Molecular Biology, [1986].
Wilson et al., Cell, 37:767 [1984].
Ben-Bassat et al., J. Bacteriol., 169:751-757 [1987].
Miller et al., Proc. Natl. Acad. Sci. USA 84:2718-1722 [1990].
Evans et al., Nature 339:385 [1989].
Huang et al., J. Virol., 62:3855 [1988].
Schlienger et al., J. Virol., 66:2 [1992].
Posnett et al., J. Biol. Chem., 263:1719 [1988].
Nardelli et al., J. Immunol., 148:914 [1992].
Hochuli et al., J. Chromatogr., 411:177 [1987].
Janknecht et al., Proc. Natl. Acad. Sci. USA 88:8972.
Narang, Tetrahedron Lett., 39:3 9 [1983].
Scott et al., Science 249:386-390 [1980].
Roberts et al., Proc. Natl. Acad. Sci. USA 89:2429-2433 [1992].
Cwirla et al., Proc. Natl. Acad. Sci. USA 87: 6378-6382 [1990].
Moore and Arnold, Nat. Biotech., 14, 458-67 [1996].
Leung et al., Technique, 1:11-15 [1989].
Eckert and Kunkel, PCR Methods Appl., 1:17-24 [1991].
Caldwell and Joyce, PCR Methods Appl., 2:28-33 [1992].
Zhao and Arnold, Nuc. Acids. Res., 25:1307-08 [1997].
Stemmer, Nature, 370:398-91 [1994].
Stemmer, Proc. Natl. Acad. Sci. USA, 91:10747-51 [1994].
Crameri et al., Nat. Biotech., 14:315-19 [1996].
Zhang et al., Proc. Natl. Acad. Sci. USA, 94:4504-09 [1997].
Crameri et al., Nat. Biotech., 15:436-38 [1997].
Kühler
Inohara Naohiro
Nuñez Gabriel
Ogura Yasunori
Casimir Jones S.C.
Desai Anand
Mondesi Robert
The Regents of the University of Michigan
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