Modulators of muscarinic receptors

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C546S122000

Reexamination Certificate

active

07446112

ABSTRACT:
The modulator compounds described herein modulate muscarinic receptors and are useful for treating muscarinic receptor mediated diseases.

REFERENCES:
patent: 6103903 (2000-08-01), Cai et al.
patent: 6166203 (2000-12-01), Cai et al.
patent: 6380209 (2002-04-01), Cai et al.
patent: 6596730 (2003-07-01), Coulton et al.
patent: 6610677 (2003-08-01), Davies et al.
patent: 6613776 (2003-09-01), Knegtel et al.
patent: 6638926 (2003-10-01), Davies et al.
patent: 6653300 (2003-11-01), Bebbington et al.
patent: 6653301 (2003-11-01), Bebbington et al.
patent: 6656939 (2003-12-01), Bebbington et al.
patent: 6660731 (2003-12-01), Bebbington et al.
patent: 6664247 (2003-12-01), Bebbington et al.
patent: 6696452 (2004-02-01), Davies et al.
patent: 6727251 (2004-04-01), Bebbington et al.
patent: 2003/0162777 (2003-08-01), Leonardi et al.
patent: 2003/0212084 (2003-11-01), Hatton et al.
patent: 2004/0152704 (2004-08-01), Altenbach et al.
patent: WO 9943682 (1999-09-01), None
patent: WO 0222601 (2002-03-01), None
Caulfield & Nigel, International Union of Pharmacology. XVII. Classification of Muscarinic Acetylcholine Receptors, Pharmacological Reviews, 50(2):279-290 (1998), p. 284.
King, Med Chem.: Principle and Practice (1994), p. 206-208.
International Search Report, Dated Apr. 26, 2005, International Application No. PCT/US2004/040839.
Abbiati, Giorgio, et al, “An efficient synthesis of 2,4-substituted [1,8] naphthyridines from 3-(2-Amino-5-methylpyridin-3-yl)-1-arylprop-2-yn-1-ones”,Synthesis, No. 13, pp. 1912-1916 (2002).
Carboni, S., et al., “Preparation and pharmacological study on some 1,2,3-triazolyl-1,8-naphthyridine derivatives,”Farmaco, Edizione Scientifica,33(5), pp. 315-323 (1978).
Caulfield, Malcolm P. et al., “Muscarinic Receptors-Characterization, Coupling, and Function,”Pharmacol. Ther.vol. 58, pp. 319-379 (1993).
Caulfield, Malcolm P. et al. “International Union of Pharmacology, XVII. Classification of Muscarinic Acetylcholine Receptors,”Pharmacological Reviews,vol. 50, No. 2, pp. 279-290 (1998).
Delapp, Neil et al., “Therapeutic Opportunities for Muscarinic Receptors in the Central Nervous System,”Journal of Medicinal Chemistry,vol. 43 No. 23, pp. 4333-4353 (2000).
Ferrarini, Pier Luigi, et al., “Synthesis and antiplatelet activity of some 1,8-naphthyridine derivatives,”European Journal of Medicinal Chemistry,Editions Scientifique Elsevier, Paris, Fr., vol. 29, pp. 735-741(1994).
Ferrarini, Pier Luigi, et al., “A novel class of highly potent and selective A1 adenosine antagonists—Structure-affinity profile of a series of 1,8-naphthyridine derivatives,”Journal of Medicinal Chemistry,vol. 43, No. 15, pp. 2814-2823 (2000).
Ferrarini, Pier Luigi, et al., “Study on Affinity Profile toward Native Human and Bovine Adenosine Receptors of a Series of 1,8-Naphthyridine Derivatives,”Journal of Medicinal Chemistry,vol. 47 No. 12, pp. 3019-3031 (2004).
Ferrarini, Pier Luigi, et al., “Synthesis of bis(2-chloroethyl)amino-1,8-naphthyridines for evaluation as anticancer agents,”Journal of Heterocyclic Chemistry,vol. 21 No. 2 pp. 417-419 (1984).
Hulme, E.C. et al., “Muscarinic Receptor Subtypes,”Annual Reviews Pharmacol. Toxicol.,vol. 30, pp. 633-673 (1990).
Macchia, Marco, et al., “4-′6-(Dansylamino)-hexylamino!-7-methyl-2-phenyl-1,8-naphthyridine as a new potential fluorescent probe for studying A1-adenosine receptor”IL Farmaco,vol. 57, No. 10, pp. 783-786 (2002).
Rivalle, Christian & Bisagni, Emile, “Ethyl (4-N-Acylaminopyridin-3-yl) glyoxylate and 5-Azaisatin as New Synthons for a Route to Various New Polyheterocycles”Journal of Heterocyclic Chem.,vol. 34, pp. 441-444 (1997).
Turner, James A., “Regiospecific Electrophilic Substitution of Aminopyridines: Ortho Lithiation of 2-,3-, and 4-(Pivaloylamino) pyridines”Journal Org. Chem.,vol. 48, pp. 3401-3408, (1983).
Zlokarnik, Gregor, et al., “Quantitation of transcription and clonal selection of single living cells with β-lactamase as reporter”Science,vol. 279, pp. 84-88 (1998).

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Modulators of muscarinic receptors does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Modulators of muscarinic receptors, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Modulators of muscarinic receptors will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-4043674

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.