Modulators of muscarinic receptors

Details Modulators of muscarinic receptors Modulators of muscarinic receptors

2011-01-04

2011-01-04

Aulakh, Charanjit S (Department: 1625)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C514S278000

Reexamination Certificate

active

07863449

ABSTRACT:
The present invention relates to modulators of muscarinic receptors. The present invention also provides compositions comprising such modulators, and methods therewith for treating muscarinic receptor mediated diseases.

REFERENCES:
patent: 3654287 (1972-04-01), Dykstra
patent: 3666764 (1972-05-01), Campbell et al.
patent: 3959475 (1976-05-01), Bauer et al.
patent: 3962259 (1976-06-01), Bauer et al.
patent: 4233307 (1980-11-01), Ono et al.
patent: 4349549 (1982-09-01), Roszkowski et al.
patent: 4558049 (1985-12-01), Bernardi
patent: 4612121 (1986-09-01), Hermansson
patent: 5091387 (1992-02-01), Evans et al.
patent: 5219860 (1993-06-01), Chambers et al.
patent: 5324733 (1994-06-01), Billington et al.
patent: 5457207 (1995-10-01), Efange et al.
patent: 5536716 (1996-07-01), Chen et al.
patent: 5576321 (1996-11-01), Krushinski, Jr. et al.
patent: 5578593 (1996-11-01), Chen et al.
patent: 5614523 (1997-03-01), Audia et al.
patent: 5627196 (1997-05-01), Audia et al.
patent: 5652235 (1997-07-01), Chen et al.
patent: 5658921 (1997-08-01), Perregaard et al.
patent: 5665725 (1997-09-01), Moltzen et al.
patent: 5693643 (1997-12-01), Gilbert et al.
patent: 5741789 (1998-04-01), Hibschman et al.
patent: 5789402 (1998-08-01), Audia et al.
patent: 5817679 (1998-10-01), Shen et al.
patent: 5885999 (1999-03-01), Elliott et al.
patent: 6013652 (2000-01-01), Maccoss et al.
patent: 6130217 (2000-10-01), Arnold et al.
patent: 6166040 (2000-12-01), Fairhurst et al.
patent: 6294534 (2001-09-01), Nargund et al.
patent: 6316437 (2001-11-01), Hoffman
patent: 6326375 (2001-12-01), Fukami et al.
patent: 6436962 (2002-08-01), Hoffman et al.
patent: 6566367 (2003-05-01), Bakthavatchalam et al.
patent: 6713487 (2004-03-01), Yu et al.
patent: 6720324 (2004-04-01), Marzabadi et al.
patent: 6828440 (2004-12-01), Goehring et al.
patent: 6869960 (2005-03-01), Ito et al.
patent: 6943199 (2005-09-01), De Lombaert et al.
patent: 7045527 (2006-05-01), Chen et al.
patent: 7205417 (2007-04-01), Fukami et al.
patent: 7279471 (2007-10-01), Mueller et al.
patent: 7351706 (2008-04-01), Bissantz et al.
patent: 7491715 (2009-02-01), Ek et al.
patent: 2002/0188124 (2002-12-01), Fukami et al.
patent: 2003/0036652 (2003-02-01), Bakthavatchalam et al.
patent: 2003/0158219 (2003-08-01), Ito et al.
patent: 2004/0054177 (2004-03-01), Otake et al.
patent: 2004/0072847 (2004-04-01), Bakthavatchalam et al.
patent: 2004/0122074 (2004-06-01), Dow et al.
patent: 2004/0142956 (2004-07-01), Chen et al.
patent: 2004/0204397 (2004-10-01), Chaturvedula et al.
patent: 2005/0033048 (2005-02-01), Bakthavatchalam et al.
patent: 2005/0143372 (2005-06-01), Ghosh et al.
patent: 2005/0153998 (2005-07-01), Ito et al.
patent: 2005/0176703 (2005-08-01), Gabriel et al.
patent: 2005/0215576 (2005-09-01), Degnan et al.
patent: 2005/0261332 (2005-11-01), Distefano et al.
patent: 2006/0019962 (2006-01-01), Makings et al.
patent: 2006/0040964 (2006-02-01), Bakthavatchalam et al.
patent: 2006/0058778 (2006-03-01), Arcusa Villacampa
patent: 2006/0106045 (2006-05-01), Hughes et al.
patent: 2006/0111380 (2006-05-01), Otake et al.
patent: 2006/0173027 (2006-08-01), Marzabadi et al.
patent: 2006/0183904 (2006-08-01), Guo et al.
patent: 2006/0211722 (2006-09-01), Jiao et al.
patent: 2006/0217372 (2006-09-01), Blanco-Pillado et al.
patent: 2006/0270673 (2006-11-01), Duggan et al.
patent: 2007/0043023 (2007-02-01), Makings et al.
patent: 2007/0149502 (2007-06-01), Chaturvedula et al.
patent: 2007/0254903 (2007-11-01), Boatman et al.
patent: 2008/0171753 (2008-07-01), Jitsuoka et al.
patent: 1535967 (2004-10-01), None
patent: 0070171 (1983-01-01), None
patent: 0414289 (1991-02-01), None
patent: 0444945 (1991-09-01), None
patent: 0486280 (1992-05-01), None
patent: 1575800 (1980-10-01), None
patent: 2308064 (1997-06-01), None
patent: 59059685 (1984-04-01), None
patent: 2001/278886 (2001-10-01), None
patent: 2002/316987 (2002-10-01), None
patent: WO 94/22846 (1994-10-01), None
patent: WO 95/11029 (1995-04-01), None
patent: WO 95/14025 (1995-05-01), None
patent: WO 95/28389 (1995-10-01), None
patent: WO 97/41878 (1997-11-01), None
patent: WO 97/41879 (1997-11-01), None
patent: WO 99/06434 (1999-02-01), None
patent: WO 99/32489 (1999-07-01), None
patent: WO 00/06146 (2000-02-01), None
patent: WO 00/06545 (2000-02-01), None
patent: WO0006153 (2000-02-01), None
patent: WO 00/38720 (2000-07-01), None
patent: WO 01/02386 (2001-01-01), None
patent: WO 01/22919 (2001-04-01), None
patent: WO 01/29027 (2001-04-01), None
patent: WO0145707 (2001-06-01), None
patent: WO0164213 (2001-09-01), None
patent: WO02094825 (2002-11-01), None
patent: WO 03/095427 (2003-11-01), None
patent: WO2004004714 (2004-01-01), None
patent: WO2004010942 (2004-02-01), None
patent: WO2004010943 (2004-02-01), None
patent: WO2004011427 (2004-02-01), None
patent: WO 2005/063745 (2005-07-01), None
patent: WO 2005/065779 (2005-07-01), None
patent: WO 2006/001958 (2006-01-01), None
International Search Report and Written Opinion of the International Searching Authority for International Application No. PCT/US2005/042967, filed Nov. 29, 2005. Forms PCT/ISA/210 & PCT/ISA/237.
Abdel-Magid, A.F. et al., “Reductive Amination of Aldehydes and Ketones with Sodium Triacetoxyborohydride. Studies on Direct and Indirect Reductive Amination Procedures,”J. Org. Chem., 61, pp. 3849-3862 (1996).
Caulfield, M.P., et al., “Classification of Muscarinic Acetylcholine Receptors,”International Union of Pharmacology. XVII.Pharmacol. Rev., 50, pp. 279-290 (1998).
Caulfield, M.P., et al., “Muscarinic Receptors-Characterization, Coupling, and Function,”Pharmacol. Ther., 58, pp. 319-379 (1993).
Chiavarelli, S. et al., “Preparation of spirocyclic template 1,2,3,4-tetrahydro-spiro[isoquinoline-4,4′-piperidine] compounds,”Gazzetta Chimica Italiana1960, 90, 189; CN1535967.
Efange, Simon M., “Spirovesamicols: Conformationally Restricted Analogues of 2-4-phenylpiperidino cyclohexanol as potential Modulators of Presynaptic Cholinergic Function,”J. Med. Chem. 1994, 37, 2574-2582.
Efange, Simon M., “Vesamicol Analogues as Sigma Ligands,”Biochemical Pharmacology, vol. 49n No. 6, pp. 791-791 (1995).
Felder, Christian C., et al., “Therapeutic Opportunities for Muscarinic Receptors in the Central Nervous System,”J. Med. Chem., 43(23), pp. 4333-4353 (2000).
Freireich, et al., “Quantitative Comparison of Toxicity of Anticancer Agents in Mouse, Rat, Hamster, Dog, Monkey and Man,”Cancer Chemother. Rep., 50: 219 (1966).
Hulme, E. C. et al., “Muscarinic Receptor Subtypes,”Ann. Rev. Pharmacol. Toxicol., 30, pp. 633-673 (1990).
Bignan, G., “Preparation of 3-Spirocyclic Indolin-2-ones as Ligands for the ORL-1 Receptor”, Bioorganic and Medicinal Chem. Lett, 15 (2005), pp. 5022-5026.
Butera, J.. “Recent Approaches to the Treatment of Urinary Incontinence: A Survey of Patent Activity from 1995 to 1998”, Expert Opinion on Therapeutic Patents, 8(8) (1998), pp. 1017-1035.
Bymaster, F., “Xanomeline: A Selective Muscarinic Agonist for the Treatment of Alzheimer's Disease”, Drug Development Research, 40 (1997), pp. 158-170.
Chambers, M., “Spiropiperidines as High-Affinity, Selective σ Ligands”, J. Med. Chem., 35(11) (1992), pp. 2033-2039.
Cheng, Y., “Solid Phase Synthesis of Spiroindoline”, Tet, Lett., 38 (1997), pp. 1497-1500.
Custers, F., “Vesamicol and Some of its Derivatives: Questionable Ligands for Selectively Labelling Acetylcholine Transporters in Rat Brain”, Eur. Jour. of Pharm., 338 (1997), pp. 177-183.
deLaszlo, S., “A Nonpeptidic Agonist Ligand of the Human C5A Receptor: Synthesis, Binding Affinity Optimization and functional Characterization”, Bioarganic and Medicinal Chem. Lett., 7(2) (1997), pp. 213-218.
Dhar, T,G., “Design and Synthesis of Novel α1a Adrenoceptor-Selective Antagonists. 2. Approaches to Eliminate Opioid Agonist Metabolites via Modification of Linker and 4-Methoxycarbonyl-4-phenylpiperidi

Affiliated with

Also associated with

Rating

Modulators of muscarinic receptors does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Modulators of muscarinic receptors, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Modulators of muscarinic receptors will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2697836