Drug – bio-affecting and body treating compositions – Immunoglobulin – antiserum – antibody – or antibody fragment,...
Patent
1996-07-26
2000-12-05
Duffy, Patricia A.
Drug, bio-affecting and body treating compositions
Immunoglobulin, antiserum, antibody, or antibody fragment,...
4241431, 4241521, 514 2, A61K 39395, A61K 3800
Patent
active
061563110
ABSTRACT:
The present invention broadly relates to the treatment, diagnosis, and prophylactic prevention of Alzheimer's disease. More specifically, the present invention relates to methods and compositions for preventing the endocytosis and cellular internalization of integral membrane amyloid .beta.-precursor protein (APP) and its subsequent catabolism by blocking or interfering with the association or binding of APP with members of the low density lipoprotein receptor family.
REFERENCES:
The Physiccans' Desk Reference.RTM., 1981 by Litton Industries 35.sup.th edition p. 1933.
Gotfries etal, European Neuropsychopharmacology 1:1-5, 1990.
McGeer etal, Neurology, 42:447-449, Feb. 1992.
Rovner, The Washington Post, Oct. 5, 1993.
Winker, JAMA, 271(13):1023-1024, 1994.
Barinagu, Science, 264:772-774, 1994.
Shrine, J., BioWorld Today, 5(123):1.
Horn, I.R. et al., "Recombinant fragments of the second cluster of complement-type repeats of LRP mediate high affinity binding of different ligands as determined by surface plasmon resonance," Fibrinolysis 10(Suppl. 3):21 (Abstract 61) (Jun. 1996).
Kounnas, M.Z. et al., "LDL Receptor-Related Protein, a Multifunctional ApoE Receptor, Binds Secreted .beta.-Amyloid Precursor Protein and Mediates Its Degradation," Cell 82:331-340 (Jul. 1995).
Kounnas, M.Z. et al., "LDL Receptor-Related Protein (LRP) Binds Secreted .beta.-Amyloid Precursor Protein and Mediates Its Degradation," Molec. Biol. Cell 6(Suppl.):327a (Abstract 1901) (Jul. 1995).
Lorent, K. et al., "Expression in Mouse Embryos and in Adult Mouse Brain of Three Members of the Amyloid Precursor Protein Family, of the Alpha-2-Macroglobulin Receptor/Low Density Lipoprotein Receptor-Related Protein and of Its Ligands Apolipoprotein E, Lipoprotein Lipase, Alpha-2-Macroglobulin and the 40,000 Molecular Weight Receptor-Associated Protein," Neuroscience 65(4):1009-1025 (Apr. 1995).
Raffai, R. et al., "Molecular characterization of two monoclonal antibodies specific for the LDL receptor-binding site of human apolipoprotein E," J. Lipid Res. 36(9):1905-1918 (Sep. 1995).
Amann, E. and J. Brosius, "`ATG vectors` for regulated high-level expression of cloned genes in Escherichia coli," Gene 40:183-190 (1985).
Ammerer, G., "Expression of Genes in Yeast Using the ADCI Promoter," Meth. Enzymol. 101:192-201 (1983).
Ashcom, J. D. et al., "The Human .alpha..sub.2 -Macroglobulin Receptor: Identification of A 420-kD Cell Surface Glycoprotein Specific for The Activated Conformation of .alpha..sub.2 -Macroglobulin," J. Cell. Biol. 110(4):1041-1048 (Apr. 1990).
Battey, F. D. et al., "The 39-kDa Receptor-associated Protein Regulates Ligand Binding by the Very Low Density Lipoprotein Receptor," J. Biol. Chem. 269(37):23268-23273 (Sep. 1994).
Bayer, E. A. et al., "The Avidin-Biotin Complex in Affinity Cytochemistry," Meth. Enzymol 62:308-315 (1979).
Beidler, C. B. et al., "Cloning and High Level Expression of a Chimeric Antibody With Specificity For Human Carcinoembryonic Antigen," J. Immunol. 141(11):4053-4060 (Dec. 1988).
Beisiegel, U. et al., "The LDL-receptor-related protein, LRP, is an apolipoprotein E-binding protein," Nature 341:162-164 (Sep. 1989).
Better, M. et al., "Escherichia coli Secretion of an Active Chimeric Antibody Fragment," Science 240:1041-1043 (May 1988).
Brown, M. S. et al., "The low-density lipoprotein receptor-related protein: double agent or decoy?" Curr. Op. Lipidol. 2(2):65-72 (Apr. 1991).
Bu, G. et al., "Low density lipoprotein receptor-related protein/.alpha..sub.2 -macroglobulin receptor is an heptic receptor for tissue-type plasminogen activator," Proc., Natl. Acad. Sci. USA 89(16):7427-7431 (Aug. 1992).
Broach, J.R. et al., "Transformation in Yeast: Development of a Hybrid Cloning Vector and Isolation of the CAN1 Gene," Gene 8(1): 121-133 (Dec. 1979).
Carrasquillo, J. A. et al., "Indium-111 T101 Monoclonal Antibody is Superior to Iodine-131 T101 in Imaging of Cutaneous T-Cell Lymphoma," J. Nucl. Med. 28(3):281-287 (Mar. 1987).
Carter, P. et al., "High Level Escherichia coli Expresion and Production of a Bivalent Humanized Antibody Fragment," Bio/Technology 10:163-167 (Feb. 1992).
Chappell, D.A. et al., "Lipoprotein Lipase Induces Catabolism of Normal Triglyceride-rich Lipoproteins via the Low Density Lipoprotein Receptor-related Protein/.alpha..sub.2 -Macroglobulin Receptor in Vitro: A Process Facilitated by Cell-Surface Proteoglycans," J. Biol. Chem. 268(19):14168-14175 (Jul. 1993).
Davis, C. G. et al., "Acid-dependent ligand dissociation and recycling of LDL receptor mediated by growth factor homology region," Nature 326:760-765 (Apr. 1987).
Edge, M. D. et al., "Total synthesis of a human leukocyte interferon gene," Nature 292:756-762 (Aug. 1981).
Engvall, E. and P. Perlmann, "Enzyme-Linked Immunosorbent Assay, Elisa III. Quantitation of Specific Antibodies by Enzyme-Labeled Anti-Immunoglobulin in Antigen-Coated Tubes," J. Immunol. 109(1):129-135 (Jul. 1972).
Esteban, J. M. et al., "New Method for the Chelation of Indium-111 to Monoclonal Antibodies: Biodistribution and Imaging of Athymic Mice Bearing Human Colon Carcinoma Xenografts," J. Nucl. Med. 28(5):861-870 (May 1987).
Glenner, G. G. and C. W. Wong, "Alzheimer's Disease: Initial Report of the Purification and Characterization of a Novel Cerebrovascular Amyloid Protein," Biochem. Biophys. Res. Comm. 120(3):885-890 (May 1984).
Goate, A. et al., Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease, Nature 349:704-706 (Feb. 1991).
Goding, J. W., "Conjugation of Antibodies With Fluorochromes: Modifications to the Standard Methods," J. Immunol. Meth. 13:215-226 (1976).
Hayden, F. G. et al., "Modification of experimental rhinovirus colds by receptor blockade," Antiviral Res. 9:233-247 (1988).
Hitzeman, R. A. et al., "Isolation and Characterization of the Yeast 3-Phosphoglycerokinase Gene (PKG) by an Immunological Screening Technique," J. Biol. Chem. 255(24):12073-12080 (Dec. 1980).
Hyman, B. T. et al., "Quantitative analysis of senile plaques in Alzheimer disease: Observation of log-normal size distribution and molecular epidemiology of differences associated with apolipoprotein E genotype and trisomy 21 (Down syndrome)," Proc. Natl. Acad. Sci. USA 92(8):3586-3590 (Apr. 1995).
Jensen, P. H. et al., "Purification of the human placental .alpha..sub.2 -macroglobulin receptor," Febs Letts. 255(2):275-280 (Sep. 1989).
Johnson-Wood, K. L. et al., "Identification of Secreted .beta.-Amyloid Precursor Protein Binding Sites on Intact Human Fibroblasts," Biochem. Biophys. Res. Comm. 200(3):1685-1692 (May 1994).
Jones, P. T. et al., "Replacing the complementarity-determining regions in a human antibody with those from a mouse," Nature 321:522-525 (May 1986).
Kang, J. et al., "The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor," Nature 325:733-736 (Feb. 1987).
Kasprzak, A. A. et al., "Location of a Contact Site between Actin and Myosin in the Three-Dimensional Structure of the Acto-S1 Complex," Biochem. 28(23):9230-9238 (Nov. 1989).
Kawasaki, G. and D. G. Fraenkel, "Cloning of yeast glycolysis genes by complementation," Biochem. Biophys. Res. Comm. 108(3):1107-1112 (Oct. 1982).
Kennedy, J. H. et al., "Protein-Protein Coupling Reactions and the Applications of Protein Conjugates," Clin. Chim. Acta 70(1):1-31 (Jul. 1976).
Kingsman, A. J. et al., "Replication in Saccharomyces cerevisiae of Plasmid pBR313 Carrying DNA from the Yeast trp1 Region," Gene 7(2):141-153 (Oct. 1979).
Kishimoto, T. K. et al., "Identification of a human peripheral lymph node homing receptor: A rapidly down-regulated adhesion molecule," Proc. Natl. Acad. Sci. USA 87(6):2244-2248 (Mar. 1990).
Kitaguchi, N. et al., "Novel precursor of Alzheimer's disease amyloid protein shows protease inhibitory activity," Nature 331:530-532 (Feb. 1988).
Knauer, D. J. et al., "Protease Nexins: Cell-Secreted Proteins That Mediate the Binding, Internalization, and Degradation of Regulatory Serine Proteases," J. Cell. Physiol. 117(3):385-396 (Dec. 1983).
Knauer, D. J. and D. D. Cunningham, "Epidermal growth factor
Hyman Bradley T.
Kounnas Maria Z.
Moir Robert D.
Strickland Dudley K.
Tanzi Rudolph E.
Duffy Patricia A.
The American National Red Cross
The General Hospital Corporation
LandOfFree
Modulators of expression and function of LRP in alzheimer's dise does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Modulators of expression and function of LRP in alzheimer's dise, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Modulators of expression and function of LRP in alzheimer's dise will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-958928