Modulators of dopamine neurotransmission

Details Modulators of dopamine neurotransmission Modulators of dopamine neurotransmission

2005-08-02

2005-08-02

Desai, Rita (Department: 1625)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C514S317000

Reexamination Certificate

active

06924374

ABSTRACT:
New 3-substituted 4-(phenyl-N-alkyl)-piperazine and 4-(phenyl-N-alkyl)-piperidine compounds of Formula (1) wherein X is N, CH, or C, however X may only be C when the compound comprises a double bind at the dotted line; R1is CF3, OSO2CF3, OSO2CH3, SOR7, SO2R7, COR7, CN, OR3, NO2, CONHR3, 3-thiophene, 2-thiophene, 3-furane, 2-furane, F, Cl, Br, or I; R2is F, Cl, Br, I, CN, CF3, CH3, OCH3, OH, and NH2; R3and R4are independently H or a C1-C4alkyl; R5is a C1-C4alkyl, an allyl, CH2SCH3, CH2CH2OCH3, CH2CH2CH2F, CH2CF3, 3,3,3-trifluoropropyl, 4,4,4-trifluorobutyl, or —(CH2)R6; R6is a C3-C6cycloalkyl, 2-tetrahydrofurane, or 3-tetra-hydrofurane; R7is a C1-C3alkyl, CF3, or N(R4)2, and pharmaceutically acceptable salts thereof are disclosed. Also pharmaceutical compositions comprising the above compounds and methods wherein the above compounds are used for treatment of disorders in the central nervous system are disclosed.

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