Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
2008-07-08
2008-07-08
Desai, Rita J (Department: 1625)
Organic compounds -- part of the class 532-570 series
Organic compounds
Heterocyclic carbon compounds containing a hetero ring...
C546S268100, C514S336000
Reexamination Certificate
active
11270046
ABSTRACT:
In various aspects, the present invention relates to non-peptidic compounds, which modulate calcitonin and amylin receptor activity; to processes for the preparation of some such compounds; and to pharmaceutical compositions including such compounds. Compounds of the invention are useful as calcitonin and/or amylin agonists and in the treatment of bone diseases and metabolic diseases.
REFERENCES:
patent: 4985242 (1991-01-01), Sekine et al.
patent: 4988512 (1991-01-01), Azria
patent: 4992417 (1991-02-01), Katsoyannis et al.
patent: 4992418 (1991-02-01), Katsoyannis et al.
patent: 5008241 (1991-04-01), Markussen et al.
patent: 5016643 (1991-05-01), Applegate et al.
patent: 5028587 (1991-07-01), Dörschug et al.
patent: 5049547 (1991-09-01), Hruby et al.
patent: 5516651 (1996-05-01), Goldring et al.
patent: 5622839 (1997-04-01), Moore et al.
patent: 5674689 (1997-10-01), Moore et al.
patent: 5674981 (1997-10-01), Moore et al.
patent: 5683884 (1997-11-01), Moore et al.
patent: 5767131 (1998-06-01), Gluchowski et al.
patent: 2005/0107419 (2005-05-01), Bhandari et al.
patent: 2001-294574 (2001-10-01), None
patent: WO 94/22829 (1994-10-01), None
patent: WO 98/37077 (1998-08-01), None
patent: WO 99/37604 (1999-07-01), None
Nyholm et. al., Amylin Receptor Agonists: a novel pharmacological approach in the management of insulin-treated diabetes mellitus, Expert Opinion Investigational Drugs (2001) 10(9), pp. 1641-1652.
Hcaplus 138:147070.
Boros, E.; Cowan, D.; Cox, R.; Mebrathutu, M.; Rabinowitz, M.; Thompson, J.; Wolfe III, L. Hantzsch Synthesis of Pyrazolo[1′,2′:1,2] pyrazolo[3,4b] pyridines: Partial Agonists of the Calcitonin Receptor. JOC Note (2005) 70 5331-5334.
Chen, W.; Armour, S.; Way, J.; Chen, G.; Watson, C.; Irving, P.; Cobb, J.; Kadwell, S.; Beaumont, K.; Rimele,T.; Kenakin, T. Expression Cloning and Receptor Pharmacology of Human Calcitonin Receptors from MCF-7 Cells and Their Relationship to Amylin Receptors. Molecular Pharmacology (1997) 52 1164-1175.
Christopoulous, G.; Perry, K..; Morfis, M.; Tilakaratine, N., Gao, Y.; Fraser, N.; Main, M.; Foord, S.; Sexton, P. Multiple Amylin Receptors Arise from Receptor Activity-Modifying Protein Interaction with the Calcitonin Receptor Gene Product. Molecular Pharmacology (2006) 56 235-242.
Cornish, J.; Naot, D. Amylin and Adrenomedullin: Novel Regulators of Bone Growth. Current Pharmaceutical Design (2006) 8 2009-2021.
Deady, L. Ring Nitrogen Oxidation of Amino Substituted Nitrogen Heterocycles with m-Chloroperbenzoic Acid. Synthetic Communications (1997) 7 509-514.
Donnici, C.; Filho, D.; Moreia, L.; Reis, G.; Cordeiro, E.; Oliveira, I.; Carvalho, S.; Paniago, E. Synthesis of the Novel 4,4′—and 6,6′—Dihydroxamic—2,2′ -Bipyridines and Mono-N-Oxide-2,2′-Bipyridine. J Braz Chem Soc (1998) 9 455-460.
Gedulin, B.; Rink, T.; Young, A. Dose-Response for Glucagonostatic Effect of Amylin in Rats. Metabolism (1997) 46 67-70.
Itoh, T.; Nagata, K.; Matsuya, Y.; Miyazaki, M.; Ohsawa, A. Reaction of Nitric Oxide with Amines. J Org Chem (1997) 62 3582-3585.
Pondel, M. Calcitonin and calcitonin receptors: bone and beyond. Int Exp Path (2000) 81 405-422.
Rushing, P.; Hagan, M.; Seeley, R.; Lutz, T. Amylin: A Novel Action in the Brain to Reduce Body Weight. Endocrinology (2000) 141 850-853.
Sexton, P.; Findlay, D.; Martin, T. Calcitonin. Current Medicinal Chemistry (1999) 6 1067-1093.
Usdin, S. Novo Develops Nasal Delivery for Insulin. BioWorld Today (Jun. 27, 1991).
Varma, R.; Kumar, D. Solid State Oxidation of 1,4-dihydropyridines to pyridines using phenyliodine (III) bis(trifluoracetate) or elemental sulfur. J Chem Soc Perkin Trans 1 (1999) 1755-1757.
Vine, W.; Beaumont, K.; Gedulin, B.; Pittner, R.; Moore, C.; Rink, T.; Young, T. Comparison of the in vitro and in vivo pharmacology of adrenomedullin, calcitonin gene-related peptide and Amylin in rats. Eur J Pharm (1996) 314 115-121.
Yadav, J.; Subba, B.; Sabitha, G.; Reddy, G. Armatization of Hantzsch 1,4-Dihydropyridines with I2-MeOH#. Synthesis (2000) 11 1532-1534.
Young, A.; Gedulin, B.; Vine, W.; Percy, A., Rink, T. Gastric emptying is accelerated in diabetic BB rats and is slowed by subcutaneous injections of Amylin. Diabetologia (1995) 38 642-648.
Delaet Nancy
Miller Stephen
Pryor Kent
Sebo Lubomir
Urban Jan
Desai Rita J
Foley & Lardner LLP
Kemia, Inc.
LandOfFree
Modulators of calcitonin and amylin receptor activity does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Modulators of calcitonin and amylin receptor activity, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Modulators of calcitonin and amylin receptor activity will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3921049