Modulators of BRCA1 activity

Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...

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4353201, 435325, 435455, 536 231, C12P 2106, C12N 1500, C12N 500, C07H 2102

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active

059486430

ABSTRACT:
Compositions of matter consisting of a family of related nucleotide sequences that encode proteins, termed BRCA1 Modulator Proteins, that bind to the tumor suppressor gene product BRCA1, and methods of using the nucleotide sequences and the proteins encoded thereby, to diagnose and/or treat disease where the BRCA1 Modulator Proteins have an apparent molecular weight of 45-97 kdaltons and are characterized by having at least one leucine zipper domain, and optionally a zinc finger domain.

REFERENCES:
Chen et al., "BRCA1 is a 220-kDa Nuclear Phosphoprotein that is Expressed and Phosphorylated in a Cell Cycle-dependent Manner"--Cancer Research, pp. 3168-3172, Jul. 1996.
Chen et al., "The Nuclear Localization Sequences of the BRCA1 Protein Interact with the Importin-Subunit of the Nuclear Transport Signal"--The JBC, vol. 271, pp. 32863-32868, Dec. 1996.
Wu et al., "Identification of a RING protein that can interact in vivo with the BRCA1 gene product" Nature Genetics, vol. 14, pp. 430-440, Dec. 1996.
Wang et al., "BRCA1 proteins are transported to the nucleus in the absence of serum and splice variants BRCA1a, BRCA1b are tyrosine phosphoproteins that associate with E2F, cyclins and cyclin dependent kinases"--Oncogene, vol. 15, pp. 143-157, 1997.
Chassin et al. Genbank, Accession Number: L06432, May 8, 1993.
Hilliler et al. Genbank, Accession Number: W17337, Apr. 29, 1996.
Hillier et al. Genband, Accession Number: R40580, May 22, 1995.

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