Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1995-03-14
1998-10-06
Russel, Jeffrey E.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
530324, 530326, 530345, A61K 3817, C07K 1113, C07K 1447
Patent
active
058176268
ABSTRACT:
Compounds that act to modulate the aggregation of natural .beta. amyloid peptides (.beta.-AP) are disclosed. The .beta. amyloid modulators of the invention can promote .beta.-AP aggregation or, more preferably, can inhibit natural .beta.-AP aggregation. Furthermore, the modulators are capable of altering natural .beta.-AP aggregation when the natural .beta.-APs are in a molar excess amount relative to the modulators. Preferred .beta. amyloid modulators comprise amino-terminally biotinylated .beta. amyloid peptide compounds. Pharmaceutical compositions comprising the compounds of the invention, and methods of altering natural .beta.-AP aggregation using the compounds of the invention, are also disclosed.
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Benjamin Howard
Findeis Mark A.
Garnick Marc B.
Gefter Malcolm L.
Hundal Arvind
DeConti, Jr. Guilio A.
Kara Catherine J.
Praecis Pharmaceuticals Incorporated
Russel Jeffrey E.
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