Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
2005-06-24
2009-02-24
Seaman, D. Margaret (Department: 1625)
Organic compounds -- part of the class 532-570 series
Organic compounds
Heterocyclic carbon compounds containing a hetero ring...
C514S312000
Reexamination Certificate
active
07495103
ABSTRACT:
The present invention relates to modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator, compositions thereof, and methods therewith. The present invention also relates to methods of treating ABC transporter mediated diseases using such modulators.
REFERENCES:
patent: 3524858 (1970-08-01), Kaminsky et al.
patent: 3992540 (1976-11-01), Clemence et al.
patent: 4107310 (1978-08-01), Allais et al.
patent: 4312870 (1982-01-01), Yokoyama et al.
patent: 4450166 (1984-05-01), Clemence et al.
patent: 4450167 (1984-05-01), Le Martret et al.
patent: 4777252 (1988-10-01), Slusarchyk et al.
patent: 4786644 (1988-11-01), Glamkowski et al.
patent: 4845105 (1989-07-01), Clemence et al.
patent: 4908366 (1990-03-01), Schriewer et al.
patent: 4956465 (1990-09-01), Schriewer et al.
patent: 5026711 (1991-06-01), Mendes et al.
patent: 5175151 (1992-12-01), Afonso et al.
patent: 5322847 (1994-06-01), Marfat et al.
patent: 5352690 (1994-10-01), Sofia et al.
patent: 5378694 (1995-01-01), Afonso et al.
patent: 5380713 (1995-01-01), Balasubramanian et al.
patent: 5412104 (1995-05-01), Afonso et al.
patent: 5491139 (1996-02-01), DeMuth et al.
patent: 5527763 (1996-06-01), Miyazaki et al.
patent: 5536727 (1996-07-01), Witzel et al.
patent: 5573868 (1996-11-01), Umemoto et al.
patent: 5610162 (1997-03-01), Witzel et al.
patent: 5663179 (1997-09-01), Dumaitre et al.
patent: 5708000 (1998-01-01), Charvet-Faury et al.
patent: 5728691 (1998-03-01), Constantino et al.
patent: 5744471 (1998-04-01), Bare et al.
patent: 5750754 (1998-05-01), Mills et al.
patent: 5753666 (1998-05-01), Beasley et al.
patent: 5804588 (1998-09-01), Dyke et al.
patent: 5807869 (1998-09-01), Furuya et al.
patent: 5834485 (1998-11-01), Dyke et al.
patent: 5840745 (1998-11-01), Buzzetti et al.
patent: 5874424 (1999-02-01), Batchelor et al.
patent: 5891878 (1999-04-01), Beasley et al.
patent: 5892114 (1999-04-01), Goldman et al.
patent: 6069151 (2000-05-01), Dyke et al.
patent: 6133265 (2000-10-01), Blum et al.
patent: 6215016 (2001-04-01), Kawai et al.
patent: 6218393 (2001-04-01), Ryder et al.
patent: 6258822 (2001-07-01), Geyer et al.
patent: 6362340 (2002-03-01), Dang et al.
patent: 6395750 (2002-05-01), Hedlund et al.
patent: 6413956 (2002-07-01), Albaugh et al.
patent: 6429207 (2002-08-01), Van Wagenen et al.
patent: 6444617 (2002-09-01), Takaishi et al.
patent: 6448254 (2002-09-01), Lubisch et al.
patent: 6515001 (2003-02-01), Saxena et al.
patent: 6544987 (2003-04-01), Guo et al.
patent: 6720344 (2004-04-01), Kerwin et al.
patent: 6723850 (2004-04-01), Guarna et al.
patent: 6790858 (2004-09-01), Strehlke et al.
patent: 6849648 (2005-02-01), Bunker et al.
patent: 6878713 (2005-04-01), De Souza et al.
patent: 6930131 (2005-08-01), Sabatucci et al.
patent: 6974806 (2005-12-01), Terashita et al.
patent: 6977001 (2005-12-01), Sauter et al.
patent: 7037913 (2006-05-01), Wang et al.
patent: 7084156 (2006-08-01), DeVita et al.
patent: 7105535 (2006-09-01), Berta et al.
patent: 7112594 (2006-09-01), Ushio et al.
patent: 7179839 (2007-02-01), Strobel et al.
patent: 2003/0195191 (2003-10-01), Burton et al.
patent: 2003/0195201 (2003-10-01), Bo et al.
patent: 2004/0033959 (2004-02-01), Chen et al.
patent: 2004/0043983 (2004-03-01), Li et al.
patent: 2004/0082798 (2004-04-01), Alonso-Alija et al.
patent: 2005/0187300 (2005-08-01), Bajji et al.
patent: 2005/0222199 (2005-10-01), Hayman et al.
patent: 2006/0148806 (2006-07-01), Watanuki et al.
patent: 2006/0178516 (2006-08-01), Johnstone et al.
patent: 2065106 (1992-10-01), None
patent: 2050966 (1971-04-01), None
patent: 2407744 (1974-08-01), None
patent: 2415763 (1974-10-01), None
patent: 3827253 (1989-03-01), None
patent: 279887 (1990-06-01), None
patent: 4017516 (1991-12-01), None
patent: 19601142 (1997-01-01), None
patent: 19532235 (1997-03-01), None
patent: 0308702 (1989-03-01), None
patent: 0332033 (1989-09-01), None
patent: 0332930 (1989-09-01), None
patent: 0343398 (1989-11-01), None
patent: 0363585 (1990-04-01), None
patent: 0472091 (1992-02-01), None
patent: 0705835 (1996-04-01), None
patent: 1224172 (2002-07-01), None
patent: 1227084 (2002-07-01), None
patent: 2324304 (1977-04-01), None
patent: 2340092 (1977-09-01), None
patent: 2537140 (1984-06-01), None
patent: 2372986 (2002-09-01), None
patent: 19880116431 (1989-11-01), None
patent: 19890168920 (1991-02-01), None
patent: 19920171521 (1994-03-01), None
patent: 19930184185 (1995-02-01), None
patent: 19930231760 (1995-03-01), None
patent: 1994278180 (1995-07-01), None
patent: 19950132761 (1996-11-01), None
patent: 19960164798 (1997-03-01), None
patent: 2000016982 (2000-01-01), None
patent: 2000256358 (2000-09-01), None
patent: 2001233859 (2001-08-01), None
patent: 2002212179 (2002-07-01), None
patent: 2002322054 (2002-11-01), None
patent: 2002322154 (2002-11-01), None
patent: 2003012667 (2003-01-01), None
patent: 2003238413 (2003-08-01), None
patent: WO9214714 (1992-09-01), None
patent: WO9218093 (1992-10-01), None
patent: WO9218483 (1992-10-01), None
patent: WO9414797 (1994-07-01), None
patent: WO9511244 (1995-04-01), None
patent: WO9615099 (1996-05-01), None
patent: WO9730999 (1997-08-01), None
patent: WO9826127 (1998-06-01), None
patent: WO9831226 (1998-07-01), None
patent: WO9905096 (1999-02-01), None
patent: WO9932436 (1999-07-01), None
patent: WO0134570 (2001-05-01), None
patent: WO0140217 (2001-06-01), None
patent: WO0203938 (2002-01-01), None
patent: WO02078693 (2002-10-01), None
patent: WO02094809 (2002-11-01), None
patent: WO2004039783 (2004-05-01), None
patent: WO2004105779 (2004-12-01), None
patent: WO2005035514 (2005-04-01), None
Perez-Guille, International J of Pharm, vol. 282(1-2), pp. 87-94, 2004.
Nosova, Chem of Het Compounds, vol. 38(8), pp. 922-928, 2002.
van Es, South African J of Chem, vol. 55, pp. 13-33, 2002.
Srivastava, J of Med Chem, vol. 43(11), pp. 2275-2279, 2000.
Theodorus Van Es and Benjamin Staskun, N,1-Dialkyl-7-(alkylamino)-4-(alkylimino)-1,4-dihydroquinoline-3-carboxamides and Their 4-Oxo Derivatives: Synthesis and Properties. S. Afr. J. Chem., 2001, 54, 102-117.
Isidor Morris Heilbron, Sydney Louis Holt and Francis Noel Kitchen, The intermolecular condensation of acetyl-methylanthranilic acid by means of phosphorus pentachloride and the formation of a complex isocyanine dye, J. Chem. Soc., 1928, 934-941.
Klaus Grohe, Helmut Heitzer, Cycloaracylierung von Enaminen, II. Synthese von 1-Amino-4-chinolon-3-carbonsäuren, Liebigs Annalen Der Chemie, 1987, 10, 871-879.
Y. Ito, T. Miyasaka, H. Fukuda, K. Akahane and Y. Kimura, Inhibition of GABAa Receptor Chloride Channel by Quinolones and Norfloxacin-Biphenylacetic Acid Hybrid Compounds, Neuropharmacology, 1996, 35 (Issues 9-10), 1263-69.
T. Imanishi, K. Akahane and N. Akaike, Evidence that a Hybrid Molecule of Norfloxacin and Biphenylacetic Acid is a Potent Antagonist at the GABAA Receptor, Neuropharmacology, 1996, 35 (Issues 9-10), 1271-77.
Hitoshi Kurata, Sayaka Suzuki, Yasuo Ohhata, Takuya Ikeda, Toru Hasegawa, Ken Kitayama, Toshimori Inaba, Keita Kono and Takafumi Kohama, A novel class of apical sodium-dependent bile acid transporter inhibitors: the amphiphilic 4-oxo-1-phenyl-1,4-dihydroquinoline derivatives, Bioorganic & Medicinal Chemistry Letters, 2004, 1183-1186.
Daniel Kaminsky, Robert I. Meltzer, Quinoline antibacterial agents. Oxolinic acid and related compounds, Journal of Medicinal Chemistry, 1968, 11(1), 160-63.
Tonghui Ma, L. Vetrivel, Hong Yang, Nicoletta Pedemonte, Olga Zegarra-Moran, Luis J. V. Galietta, and A. S. Verkman, High-affinity Activators of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Chloride Conductance Identified by High-throughput Screening, J. Biol. Chem., 2002, 277(40), 37235-41.
Laurent F. Hennequin et al., Design and Structure-Activity Relationship of a New Class of Potent VEGF Receptor Tyrosine Kinase Inhibitors, J. Med. Chem., 1999, 42 (26), 5369-5389.
R. K. Haynes and F. R. Hewgill, Amine oxidation and the chemistry of quinone imines. Part I. 3-Methoxy-4-t-butylaniline, J. Chem. Soc., Perkin Trans.
Grootenhuis Peter
Hadida-Ruah Sara
Hazelwood Anna
McCartney Jason
Singh Ashvani
Brennan Nancy K.
Govindaswamy Nandakumar
Seaman D. Margaret
Vertex Pharmaceuticals Incorporated
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