Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Reexamination Certificate
2007-07-17
2007-07-17
Haddad, Maher M. (Department: 1644)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
Reexamination Certificate
active
09935124
ABSTRACT:
The present invention relates to regulation of angiogenesis. More particularly, the present invention is directed to nucleic acids encoding C1-angiogenesis protein, also called integrin-linked kinase associated protein (“ILKAP”) and ILKAP protein, which is involved in modulation of angiogenesis. The invention further relates to methods for identifying and using agents, including small organic molecules, antibodies, peptides, cyclic peptides, nucleic acids, antisense nucleic acids, and ribozymes, that modulate angiogenesis via modulation of ILKAP and ILKAP-related cascades; as well as to the use of expression profiles and compositions in diagnosis and therapy of angiogenesis.
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Leung-Hagesteijn, C. et al., “Modulation of integrin signal transduction by ILKAP, a protein phosphatase 2C associating with the integrin-linked kinase, ILK1,” EMBO J., vol. 20, No. 9, pp. 2160-2170 (2001).
Leung-Hagesteijn et al. “Modulation of integrin signal transduction by ILKAP, a protein phosphatase 2C associating with the integrin-linked kinase, ILK1” EMBO Jnl., May 1, 2001, vol. 20, No. 9, pp. 2160-2170.
Atchison Robert E.
Bogenberger Jakob
Lorens James B.
Xu Weiduan
Haddad Maher M.
Rigel Pharmaceuticals Inc.
Townsend and Townsend and Crew
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