Modulators of actin

Details Modulators of actin Modulators of actin

1998-05-18

1999-11-16

Achutamurthy, Ponnathapu

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

4352523, 435 691, 435325, 4353201, 435 86, 5303871, C12Q 100, C12P 2106, C12P 1942, C07K 1600

Patent

active

059855746

ABSTRACT:
The invention provides methods and compositions which find use, inter alia, for modulating the stabilization of actin filaments. The compositions may comprise one or more polypeptide moieties derived from a novel human diaphanous polypeptide and/or one or more nucleic acid moieties derived from a novel human diaphanous gene or gene transcript. The invention also provides agents which specifically modify the binding of a natural human diaphanous gene or gene product with a natural binding target thereof, isolated human diaphanous hybridization probes and primers capable of specifically hybridizing with the disclosed human diaphanous genes, human diaphanous-specific binding agents such as specific antibodies, and methods of making and using the subject compositions in diagnosis, therapy and in the biopharmaceutical industry.

REFERENCES:
Watanabe et al., EMBO J., 16(11), 3044-3056, Jun. 1997.

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