Modulators of acetylcholine receptors

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C546S127000, C546S126000

Reexamination Certificate

active

07148236

ABSTRACT:
The present invention relates to compounds that modulate neurotransmission by promoting the release of neurotransmitters such as acetylcholine, dopamine and norepinephrine. More particularly, the present invention relates to thio-bridged aryl compounds that are capable of modulating acetylcholine receptors and pharmaceutical compositions comprising such compounds. The compounds disclosed are useful for the treatment of dysfunctions of the central and autonomic nervous systems.

REFERENCES:
patent: 5306723 (1994-04-01), Chenard
patent: 5498610 (1996-03-01), Chenard
patent: 6046213 (2000-04-01), Chenard et al.
patent: 0 398 578 (1997-03-01), None
patent: 04054181 (1992-02-01), None
patent: 96/37226 (1996-11-01), None
patent: WO 96/37226 (1996-11-01), None
patent: WO 97/19059 (1997-05-01), None
patent: WO 99/32117 (1999-07-01), None
patent: WO 00/44755 (2000-08-01), None
patent: WO 01/19817 (2001-03-01), None
Abreo et al., “Novel 3-pyridyl ethers with subnanomolar affinity for central neuronal nicotinic acetylcholine receptors”, Journal of Medicine Chemistry, vol. 39, pp. 817-825.
Hu et al., “Regional vascular and cardiac responses to systemic neuropeptide-Y in normal and diabetic rats”, Peptieds, vol. 18, pp. 809-815.
Kraiss, G. et al., Stereospecific Methods of Forming Ethers by Nucleophilic Reactions of 3α-Substituted Tropanes,The Journal of Organic Chemistry, Jun. 1968, 2601-2603, vol. 33, No. 6.
Elliott, R.L.et al., 2-(Aryloxymethyl) Azacyclic Analogues as Novel Nicotinic Acetylcholine Receptor (nAChR) Ligands,Bioorganic&Medicinal Chemistry Letters, 1996, 2283-2288, vol. 6, No. 19.
Radl S. et al., Synthesis and Analgesic Activity of Some Side-Chain Modified Anpirtoline Derivatives,Arch. Pharm. Pharm. Med. Chem., 2000, 107-112, vol. 333.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Modulators of acetylcholine receptors does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Modulators of acetylcholine receptors, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Modulators of acetylcholine receptors will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-3681313

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.