Modulation of the sensitivity of tumor cells to chemotherapeutic

Details Modulation of the sensitivity of tumor cells to chemotherapeutic Modulation of the sensitivity of tumor cells to chemotherapeutic

1997-12-10

2000-07-25

Minnifield, Nita

Drug, bio-affecting and body treating compositions

Radionuclide or intended radionuclide containing; adjuvant...

Attached to antibody or antibody fragment or immunoglobulin;...

424 149, 424 91, 424 9322, 424 141, 424 117, 424 937, 424 851, 424 852, 424 931, 4241551, 4241521, 424520, 424534, 4353722, A61K 5100, A61K 3100, A61K 3940, A61K 39395

Patent

active

06093381&

ABSTRACT:
Disclosed is a method for improving the treatment of a cancer patient which is undergoing (adjuvant) chemotherapy. Prior to or concomitant with the patient receiving adjuvant chemotherapy, the patient is administered mitogenically stimulated lymph node lymphocytes or the supernatant therefrom. The lymph node lymphocytes are patient excised lymph node lymphocytes enriched in tumor reactive cells, such as CD4+ tumor reactive cells. Radiolabeled locators (e.g., antibodies) can be used along with a portable radiation detector to intraoperatively determine which lymph nodes bear lymph node lymphocytes enriched in tumor reactive cells. The patient excised lymph node lymphocytes enriched in tumor reactive cells then are subjected to mitogenic stimulation for their expansion and administration to the patient.

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