Modulation of the integrin linked kinase signaling pathway...

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving transferase

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

Reexamination Certificate

active

07923218

ABSTRACT:
Modulation of the integrin-linked kinase (ILK) signaling pathway is used to enhance the remodeling process relevant to a wide range of cardiac diseases. More specifically, a process to instigate beneficial human cardiac hypertrophy or for post myocardial infarction (MI) remodeling comprising illiciting an overexpression of ILK, is described. The ILK signaling pathway is also used as a means for cardiac stem cell proliferation and self-renewal.

REFERENCES:
patent: 6013782 (2000-01-01), Dedhar et al.
patent: 6699983 (2004-03-01), Dedhar et al.
patent: 2004/0220125 (2004-11-01), Coles et al.
patent: 2005/0054599 (2005-03-01), Coles et al.
patent: 2006/0121496 (2006-06-01), Srivastava et al.
patent: 2008/0214799 (2008-09-01), Coles et al.
patent: 2609937 (2006-11-01), None
patent: 2610521 (2006-11-01), None
patent: WO 2006/125321 (2006-11-01), None
patent: WO 2006/125322 (2006-11-01), None
patent: WO 2007/137414 (2007-12-01), None
Bock-Marquette I. et al. Thymosin Beta4 Activates Integrin Linked Kinase and Promotes Cardiac Cell Migration, Survival and Cardiac Repair. Nature vol. 432, pp. 466-472, Nov. 25, 2004.
Pham C. et al. Striated Muscle Specific Beta 1D Integrin and FAK are Involved in Cardiac Myocyte Hypertrophic Response Pathway. Am J Physiol Heart Circ Physiol 279:2916-2926, 2000.
Anversa P, et al., “Myocyte renewal and ventricular remodelling.”Nature,415: pp. 240-243 (2002).
Araki H, et al. “Expansion of human umbilical cord blood SCID-repopulating cells using chromatin-modifying agents.”Exp Hexnatol., 34: pp. 140-149 (2006).
Austin TW, et al., “A role for the Wnt gene family in hematopoiesis: expansion of multilineage progenitor cells.”Blood89: No. 10: pp. 3624-3635 (1997).
Beltrami AP, et al., “Adult cardiac stem cells are multipotent and support' myocardial regeneration.”Cell, pp. 114: pp. 763-776 (2003).
Choi JH, et al., “Augmentation of Therapeutic Angiogenesis Using Genetically Modified Human Endothelial Progenitor Cells with Altered Glycogen Synthase Kinase-3β Activity.”J Biol Chem., 279: No. 47: pp. 49430-49438 (2004).
Coles JG, et al.,“Cardioprotective stress response in the human fetal heart.”JTCVS, 129: pp. 1128-1136 (2005).
Eckfeldt CE, et al., “The molecular repertoire of the ‘Almighty’ stem cell.” Nature, vol. 6:Nat Rev Mol Cell Biol., pp. 726-737 (2005).
Gerber HP, et al., “VEGF regulates haematopoietic stem cell survival by an internal autocrine loop mechanism.”Nature, 417: pp. 954-958 (2002).
Hannigan GE, et al., “Regulation of cell adhesion and anchorage-dependent growth by a new beta 1integrin-linked protein kinase.”Nature, 379: pp. 91-96 (1996).
Hannigan G, et al., “Integrin-linked kinase: a cancer therapeutic target unique among its ILK.”Nat Rev Cancer,5: pp. 51-63 (2005).
Konstantinov IE, et al. “Gene expression profiles in children undergoing cardiac surgery for right heart obstructive lesions.”J Thorac Cardiovasc Surg.,vol. 127: No. 3: pp. 746-754 (2004).
Kumar AS, et al., “ILKAP regulates ILK signaling and inhibits anchorage-independent growth.”Oncogene, 23: pp. 3454-3461 (2004).
Laugwitz KL, et al., “Postnatal isl1+ cardioblasts enter fully differentiated cardiomyocyte lineages.”Nature, vol. 433: pp. 647-653 (2005).
Lee A, et al., “Isolation of neural stem cells from the postnatal cerebellum.”Nature Neuroscience, vol. 8: pp. 723-729 (2005).
Leung-Hagesteijn C, et al., “Modulation of integrin signal transduction by ILKAP, a protein phosphatase 2C associating with the integrinlinked kinase, ILK1.”EMBO J., vol. 20: No. 9: pp. 2160-70 (2001).
Liu BY et al., “The transforming activity of Wnt effectors correlates with their ability to induce the accumulation of mammary progenitor cells.”Proc Natl Acad Sci USA, vol. 101: No. 12: pp. 4158-4163 (2004).
Matsuura K, et al., “Adult cardiac Sea-1-positive cells differentiate into beating cardiomyocytes.”J Biol Chem., vol. 279: No. 12: pp. 11384-11391 (2004).
Messina E, et al. “Isolation and expansion of adult cardiac stem cells from human and murine heart.”Circ Res., 95: pp. 911-921 (2004).
Miller MG, et al., “Integrin-linked kinase is a positive mediator of L6 myoblast differentiation.”Biochem Biophys Res Commun.,310: pp. 796-803 (2003).
Milosevic J. et al., “Cyropreservation does not affect proliferation and multipotency of murine neural precursor cells.”Stem Cells, 23: pp. 681-688 (2005).
Nelson W. et al., “Convergence of Wnt, beta-catenin, and cadherin pathways.”Science,.vol. 303: pp. 1483-1487 (2004).
Novak A, et al., “Cell adhesion and the integrin-linked kinase regulate the LEF-1 and beta-catenin signaling pathways.”Proc Natl Acad Sci USA, vol. 95: pp. 4374-4379 (1998).
Novak A, et al., “Signaling through beta-catenin and Lef/Tcf.”Cell Mol Life Sci, 56: pp. 523-537 (1999).
Oh H, et al., “Cardiac muscle plasticity in adult and embryo by heart-derived progenitor cells.”Ann NY Acad Sci.,1015: pp. 182-189 (2004).
Persad S, et al., Inhibition of integrin-linked kinase (ILK) suppresses activation of protein kinase B/Akt and induces cell cycle arrest and apoptosis of PTEN-mutant prostate cancer cells.Proc Natl Acad Sci USA,; vol. 97: No. 7: pp. 3207-3212 (2000).
Reya T, et al., “Wnt signalling in stem cells and cancer.”Nature, vol. 434: pp. 843-850 (2005).
Reya T, et al., “A role for Wnt signalling in self renewal of haematopoietic stem cells.”Nature, vol. 423: pp. 409-414 (2003).
Sato N. et al., “Maintenance of pluripotency in human and mouse embryonic stem cells through activation of Wnt signaling by a pharmacological GSK-3-specific inhibitor.”Nat Med,.vol. 10: pp. 55-63 (2004).
Tan C, et al., “Inhibition of integrin linked kinase (ILK) suppresses beta-cateninLef/Tcf-dependent transcription and expression of the E-cadherin repressor, snail, in APC-/- human colon carcinoma cells.”Oncogene, vol. 20: pp. 133-140 (2001).
Troussard AA, et al., Cell-extracellular matrix interactions stimulate the AP-1 transcription factor in an integrinlinked kinase- and glycogen synthase kinase 3dependent manner.:Mol. Cell. Biol.,vol. 19: No. 11: pp. 7420-7427 (1999).
Troussard AA, et al. “Conditional knock-out of integrin-linked kinase demonstrates an essential role in protein kinase B/Akt activation.”J Biol Chem.,vol. 278: No. 25: pp. 22374-22378 (2003).
Xie D, et al., “Cyr61 is overexpressed in gliomas and involved in integrin-linked kinase-mediated Akt and beta-catenin-TCF/Lef signaling pathways.”Cancer Res,.64: pp. 1987-1996 (2004).
Yamataka A, et al., “Abnormal distribution of intestinal pacemaker (C-KIT-positive) cells in an infant with chronic idiopathic intestinal pseudoobstruction.”,J Pediatr Surg; vol. 33: No. 8: pp. 859-862 (1998).
Zechner D, et al., “β-Catenin signals regulate cell growth and the balance between progenitor cell expansion and differentiation in the nervous system.”Dev Biol., 258: pp. 406-418 (2003).
Freund, C. et al. “Requirement of nuclear factor kappaB in angiotensin II- and isoproterenol-induced cardiac hypertrophy in vivo”,Circulation, 111: p. 2319-2325 (2005).
Kee, HJ et al., “Inhibition of histone deacetylation blocks cardiac hypertrophy induced by angiotensin II infusion and aortic banding.”Circulation, 113: pp. 51-59 (2006).
Wu et al., “Integrin-linked kinase (ILK) and its interactions: a new paradigm for the coupling of extracellular matrix to actin cytoskeleton and signaling complexes.”J. Cell Biology, 155 (4). pp. 505-510 (2001).

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Modulation of the integrin linked kinase signaling pathway... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Modulation of the integrin linked kinase signaling pathway..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Modulation of the integrin linked kinase signaling pathway... will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-2631871

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.