Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...
Reexamination Certificate
2006-01-04
2010-11-09
Pak, Michael (Department: 1646)
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Blood proteins or globulins, e.g., proteoglycans, platelet...
Reexamination Certificate
active
07829672
ABSTRACT:
A novel tetrodotoxin resistant sodium channel is described, along with isolated nucleotides that encode this receptor. Methods for identifying agents that modulate the Na+current through the receptor are provided, as well as related therapeutic and diagnostic methods.
REFERENCES:
patent: 6184349 (2001-02-01), Herman et al.
patent: 2332906 (1999-07-01), None
patent: WO-9701577 (1997-01-01), None
patent: WO-9947670 (1999-09-01), None
Akopian et al, (1997) “Structure and distribution of a broadly expressed atypical sodium channel,” FEBS Letters, 400:183-187.
Akopian et al. (1996) “A tetrodotoxin-resistant voltage-gated sodium channel expressed by sensory neurons,” Nature, 379:257-262.
Arbuckel et al. (1995) “Expression of tetrodotoxin-resistant sodium channels in capsaicin-sensitive dorsal root ganglion neurons of adult rats,” Neurosci. Lett., 185:70-73.
Beckh, S. et al. (1989) “Differential regulation of three sodium channel messenger RNA's in the rat central nervous system during development,” EMBO J., 8:3611-3616.
Black et al. (1994) “Sodium channel mRNAs in cultured spinal cord astrocytes: in situ hybridization in identified cell types,” Molecular Brain Research, 23: 235-245.
Cannon, S.C. (1996) “Ion-channel defects and aberrant excitability in myotonia and periodic paralysis,” Trends Neurosci., 19(1):3-10.
Cannon, S.C. (1997) “From mutation to myotonia in sodium channel disorders,” Neuromuscul. Disord. 7:241-249.
Catterall, W.A. (1993) “Structure and function of voltage-gated ion channels,” Trends Neurosci., 16(12):500-508.
Cummins et al. (1997) “Downregulation of tetrodotoxin-resistant sodium currants and upregulation of a rapidly repriming tetrodotoxin-sensitive sodium current in small spinal sensory neurons after nerve injury,” J. Neuroscience, 17:3503-3514.
Dib-Hajj et al. (1997) “Insertion of a SNS-specific tetrapeptide in S3-S4 linker of D4 accelerates recovery from inactivation of skeletal muscle voltage-gated Na Channel μ1 in HEK 293 cells,” FEBS Letters 416: 11-14.
Dib-Hajj et al. (1998) “NaN, a novel voltage-gated Na channel, is expressed preferentially in peripheral sensory neurons and down-regulated after axotomy,” Proc. Natl. Acad. Sci. USA, 95:8963-8968.
Dib-Hajj, S. (1996) “Down-regulation of transcripts for Na channel α-SNS in spinal sensory neurons following axotomy,” Proc. Natl. Acad. Sci. USA, 93:14950-14954.
England, S. (1996) “PGE2 modulates the tetrodotoxin-resistant sodium current in neonatal rat dorsal root ganglion neurones via the cyclic AMP-protein kinase cascade,” J. Physiology 495(2):429-440.
Felipe et al. (1994) “Primary structure and differential expression during development and pregnancy of a novel voltage-gated sodium channel in the mouse,” J. Biol. Chem., 269:30125-30131.
Fjell et al. (1997) “Differential expression of sodium channel genes in retinal ganglion cells,” Molecular Brain Research, 50:197-204.
George et al. (1993) “Genomic organization of the human skeletal muscle sodium channel gene,” Genomics, 15:598-606.
Gold et al. (1996) “Hyperalgesic agents increase a tetrodotoxin-resistant Na+current in nociceptors,” Proc. Natl. Acad. Sci. USA, 93:1108-1112.
Goldin, A. L. (1995) Handbook of receptors and channels, pp. 73-100, North, R.A., Ed., CRC press, Boca Raton, FL.
Gu, X. Q. (1997) “TTX-sensitive and -resistant Na+currents, and mRNA for the TTX-resistant rH1 channel, are expressed in B104 neuroblastoma clells,” J. Neurophysiology, 77:236-246.
Mandel, G. (1992) “Tissue-specific expression of the voltage-sensitive sodium channel,” J. Membrane Biology, 125:193-205.
McClatchey, A. I. (1992) “The genomic structure of the human skeletal muscle sodium channel gene,” Hum. Mol. Genet., 1(7):521-527.
Ptacek, L..J. (1997) “Channelopathies: ion channel disorders of muscle as a paradigm for paroxysmal disorders of the nervous system,” Neuromuscul. Disord., 7:250-255.
Rizzo et al. (1994) “Slow sodium conductances of dorsal root ganglion neurons: intraneuronal homogeneity and interneuronal heterogeneity,” J. Neurophysiology, 72(6):2796-2815.
Rizzo et al. (1995) “Selective loss of slow and enhancement of fast Na+currents in cutaneous afferent dorsal root ganglion neurones following axotomy,” Neurobiol. Dis., 2:87-96.
Rizzo et al. (1996) “Mechanisms of paresthesiae, dysesthesia, and hyperesthesiae: role of Na+channelheterogeneity,” European Neurology, 36:3-12.
Roden et al. (1997) “Structure and function of cardiac sodium and potassium channels,” Am. J. Physiol., 273:H511-525.
Rush et al. (1997) “Phenytoin and carbamazepine: differential inhibition of sodium currents in small cells from adult rat dorsal root ganglia,” Neurosci. Lett., 226:95-98.
Sangameswaran et al. (1996) “Structure and function of a novel voltage-gated, tetrodotoxin-resistant sodium channel specific to sensory neurons,” J. Biol. Chem., 271(11):5953-5956.
Sontheimer et al. (1992) “Ion channels in spinal cord astrocytes in vitro. II. Biophysical and pharmacological analysis of two Na+current types,” J. Neurophysiology, 68(4):1001-1011.
Sontheimer et al. (1994) “Astrocyte Na+channels are required for maintenance of Na+/ K+-ATPase activity,” J. Neuroscience, 14(5):2464-2475.
Souslova et al. (1997) “Cloning and characterization of a mouse sensory neuron tetrodotoxin-resistant voltage gated sodium channel gene, Scn10a,” Genomics, 41:201-209.
Tate et al. (1998) “Two sodium channels contribute to the TTX-R sodium current in primary sensory neurons,” Nat. Neurosci. 1:653-655.
Wang et al. (1996) “Genomic organization of the human SCN5A gene encoding the cardiac sodium channel,” Genomics, 34: 9-16.
Waxman et al. (1994) “Type III sodium channel mRNA is expressed in embryonic but not adult spinal sensory neurons, and is reexpressed following axotomy,” J. Neurophysiology, 72:466-470.
Waxman et al. (1996) “Expression of mRNA for sodium channel in subfamily 2 in spinal sensory neurons,” Neurochem. Res., 21:395-401.
Zur et al. (1995) “Differential up-regulation of sodium channel α- and β1-subunit mRNAs in cultured embryonic DGR. neurons following exposure to NGF,” Molecular Brain Research, 30:97-105.
Dib-Hajj Sulayman
Waxman Stephen G.
Choate Hall & Stewart LLP
Herschbach Jarrell Brenda
Nguyen Suzanne P.
Pak Michael
Yale University
LandOfFree
Modulation of sodium channels in dorsal root ganglia does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Modulation of sodium channels in dorsal root ganglia, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Modulation of sodium channels in dorsal root ganglia will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-4245948