Modulation of secondary metabolite production by zinc...

Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process...

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C435S043000, C435S047000, C435S067000, C435S072000

Reexamination Certificate

active

10149310

ABSTRACT:
Methods for improving the production of a secondary metabolite by a fungus by increasing the yield or productivity of the secondary metabolite produced by the fungus are described. The methods include increasing the expression of LYS14, for example, by transforming a cell with a nucleic acid molecule encoding LYS14.

REFERENCES:
patent: 2002/0128250 (2002-09-01), Busby et al.
patent: WO 00/20596 (2000-04-01), None
patent: WO 00/37629 (2000-06-01), None
Martegani et al. Yeast 9: 575-582, 1997.
Katz et al. Isolation and Analysis of the Acetate Regulatory Gene, facB, from Aspergillus nidulans. Mol. Cell. Biol. 9:5696-5701 1989.
Penalva et al., “The optimization of penicillin biosynthesis in fungi” Trends in Biotech. 16:483-489, 1998.
Suarez et al., “Characterization of aPenicillium chrysogenumgene encoding a PacC transcription factor and its . . . ” Mol. Microbiol. 20:529-540, 1996.
Todd et al., “Evolution of a fungal regulatory gene family: The Zn(II)2Cys6 binuclear cluster DNA binding motif” Fungal Genet. and Biol. 21:388-405, 1997.
Van Peij et al., “Isolation and analysis of xInR, encoding a transcriptional activator co-ordinating xylanolytic . . . ” Mol. Microb. 27:131-142, 1998.
Wang et al., “Yeast transcriptional regulator Leu3p” J. of Biol. Chem. 274:19017-19024, 1999.
Zhou et al., “Yeast regulatory protein LEU3: a structure-function analysis” Nucl. Acids Res. 18:291-298, 1990.
Carvajal et al., “Molecular and phenotypic characterization of yeast PDR1 mutants that show . . . ” Mol. Gen. Genet. 256:406-415, 1997.
Casqueiro et al., “Gene targeting inPenicillium chrysogenum: Disruption of thelys2gene . . . ” J. of Bacteriol. 181:1181-1188, 1999.
Chang et al., “Increased expression ofAspergillus parasiticus aflR, encoding a sequence-specific DNA-binding protein . . . ” Applied and Env. Microbiol. 61:2372-2377, 1995.
Crowley et al., “A mutation in a purported regulatory gene affects control of sterol uptake . . . ” J. of Bacteriol. 180:4177-4183, 1998.
D'Alessio et al., “Cross-pathway regulation inSaccharomyces cerevisiae: Activation of the proline utilization . . . ” J. of Bacteriol. 182:3748-3753, 2000.
Dickson et al., “Genetic evidence for similar negative regulatory domains in the yeast transcription . . . ” Nucl. Acids. Res. 18:5213-5217, 1990.
Friden et al., “A large internal deletion converts yeast LEU3 to a constitutive transcriptional activator” Mol. and Cel. Biol. 9:4056-4060, 1989.
Haas et al., “NRE, the major nitrogen regulatory protein ofPenicillium chrysogenum, binds specifically to elements in the . . . ” Curr. Genet. 28:177-183, 1995.
Hasper et al., “TheAspergillus nigertranscriptional activator XinR, which is involved in . . . ” Mol. Microbiol. 36:193-200, 2000.
Marczak et al., “Analysis of constitutive and noninducible mutations of the PUT3 transcriptional activator” Mol. and Cell. Biol. 11:2609-2619, 1991.
Mingot et al., “Disruption ofphacA, anAspergillus nidulansgene encoding a novel cytochrome P450 monooxygenase . . . ” J. of Biol. Chem. 274:14545-14550, 1999.
Nourani et al., “Clustered amino acid substitutions in the yeast transcription regulator Pdr3p increase pleiotropic . . . ” Mol. Gen. Genet. 256:397-405, 1997.
Oestreicher et al., “A single amino acid change in a pathway-specific transcription factor results in differing . . . ” J. Mol. Biol. 249:693-699, 1995.
Ehrlich et al., “Alteration of Different Domains in AFLR Affects Aflatoxin Pathway Metabolism inAspergillus parasiticusTransformants” Fungal Gen. And Biol. 23:279-287, 1998.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Modulation of secondary metabolite production by zinc... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Modulation of secondary metabolite production by zinc..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Modulation of secondary metabolite production by zinc... will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-3809532

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.