Modulation of receptor-mediated ion transport

Details Modulation of receptor-mediated ion transport Modulation of receptor-mediated ion transport

1991-09-12

1993-05-18

Waddell, Frederick E.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Cyclopentanohydrophenanthrene ring system doai

514179, 514182, A61K 3156

Patent

active

052121674

ABSTRACT:
The subject application discloses methods for modulating NMDA-mediated ion transport, and inhibiting non-NMDA glutamate-induced ion transport, in neuronal cells. The methods involve contacting a neuronal cell with an effective amount of the neurosteroid pregnenolone sulfate, or pharmacologically effective derivatives thereof.

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Majewska, Brain Research 526:143-146 (1990).
CA 115(19):198924p, Wu et al., 1991.

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