Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving hydrolase
Reexamination Certificate
2006-06-06
2006-06-06
Saidha, Tekchand (Department: 1652)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving hydrolase
C435S196000, C435S320100, C435S252300, C536S023200, C530S300000
Reexamination Certificate
active
07056692
ABSTRACT:
The mechanism by which pleiotrophin binds to the receptor protein tyrosine phosphatase β/ζ(RPTP β/ζ) is disclosed along with methods of modulating both pleiotrophin expression and signaling to treat, prevent and inhibit abnormal cell growth states. Specifically provided are methods of inhibiting tumor growth, promotion, metastasis, invasiveness and angiogenesis as well as methods of preventing or inhibiting cell adhesion.
REFERENCES:
patent: 01/64944 (2001-09-01), None
patent: WO 01/96394 (2001-12-01), None
Zhang et al., “Human Breast Cancer Growth Inhibited in Vivo by a Dominant Negative Pleiotrophin Mutant,” J. Biol. Chem., 1997, pp. 16733-16736, vol. 272.
Meng et al., “Pleiotrophin Signals Increased Tyrosine Phosphorylation of B-catenin Through Inactivation of the Intrinsic Catalytic Activity of the Receptor-Type Protein Tyrosine Phosphatase B/C,” PNAS, 2000, pp. 2603-2608, vol. 97.
Maeda, Nobuaki, et al., A Receptor-like Protein-tyrosine Phosphatase PTPζRPTPβ Binds a Heparin-binding Growth Factor Midkine; The Journal of Biological Chemistry, Apr. 30, 1999, pp. 12474-12479, vol. 274, No. 18.
Maeda, Nobuaki, et al., 6B4 Proteoglycan/Phosphacan, an Extracellular Variant of Receptor-like Protein-tyrosine Phosphatase ζRPTPβ, Binds Pleiotrophin/Heparin-binding Growth-associated Molecule (HB-GAM), The Journal of Biological Chemistry, Aug. 30, 1996, pp. 21446-21452, vol. 271, No. 35.
Milev, Peter, et al., High Affinity Binding and Overlapping Localization of Neurocan and Phosphacan/Protein-tyrosine Phosphatase-ζ/β with Tenascin-R, Amphoterin, and the Heparin-binding Growth-associated Molecule, The Journal of Biological Chemistry, Mar. 20, 1998, pp. 6998-7005, vol. 273, No. 12.
Maeda, Nobuaki, et al., Involvement of Receptor-like Protein Tyrosine Phosphatase ζ/RPTPβ and its Ligand Pleiotrophin/Heparin-binding Growth-associated Molecule (HB-GAM) in Neuronal Migration, The Journal of Cell Biology, Jul. 13, 1998, pp. 203-216, vol. 142, No. 1.
Li, Yue-Sheng, et al., Pleiotrophin Stimulates Tyrosine Phosphorylation in NIH 3T3 and NB41A3 Cells, Biochemical and Biophysical Research Communications, Sep. 15, 1993, pp. 1089-1095, vol. 195, No. 2.
Barnes-Jewish Hospital
Saidha Tekchand
Sonnenschein Nath & Rosenthal LLP
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