Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Reexamination Certificate
2005-09-16
2009-08-18
Huynh, Phuong (Department: 1644)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
C435S007710, C435S007720, C435S007920, C435S007930, C435S007950, C435S008000, C435S069700, C435S069800, C435S252200, C435S252800, C435S254110, C530S329000, C530S350000
Reexamination Certificate
active
07575881
ABSTRACT:
Screening assays that allow for the identification of agents that modulate the activity of the arginylation branch of the N-end rule pathway are provided. Also provided are method of using an agent that modulate the activity of the arginylation branch of the N-end rule pathway to increase or decrease protein degradation in a cell, and to modulate physiologic and pathologic associated with N-end rule pathway mediated arginylation.
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Gonda et al., “Universality and Structure of the N-end Rule”,The Journal of Biological Chemistry, 264(28):16700-16712 (1989).
Hu Rong-Gui
Kashina Anna
Kwon Yong Tae
Sheng Jun
Varshavsky Alexander
California Institute of Technology
DLA Piper (LLP) US
Huynh Phuong
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