Modulation of inflammatory responses by administration of GMP-14

Details Modulation of inflammatory responses by administration of GMP-14 Modulation of inflammatory responses by administration of GMP-14

1989-03-08

1995-01-03

Walsh, Stephen G.

Drug, bio-affecting and body treating compositions

Immunoglobulin, antiserum, antibody, or antibody fragment,...

Monoclonal antibody or fragment thereof

514 8, A61K 39395, A61K 3702

Patent

active

053784642

ABSTRACT:
A method using compounds inhibiting binding reactions involving GMP-140 to modulate an inflammatory response. The method is based on the discovery that GMP-140, released from the storage granules of platelets, endothelial cells, and megakaryocytes, and redistributed to the surface of the cells within seconds of activation by mediators such as thrombin, ionophores or histamine, binds to a ligand on neutrophils, and the plasma proteins C3b and protein S. Adhesion of the cells following activation is blocked directly by administration of antibody to GMP-140 or its ligand, or by competitive inhibition by administration of soluble GMP-140, the GMP-140 ligand, or the specific carbohydrate portion of the ligand bound by GMP-140.

REFERENCES:
patent: 4605644 (1986-08-01), Foker
patent: 5114842 (1992-05-01), Plow et al.
Issekutz, A., et al., Laboratory Invest. vol. 49, No. 6, pp. 716-724 (1983).
McEver, R., et al., J. Biol. Chem., vol. 259, No. 15, pp. 9799-9804 (Aug. 10, 1984).
Stenberg, P., et al., J. Cell. Biol., vol. 101, pp. 880-886 (Sep. 1985).
McEver, et al., Blood 70(5) Suppl. 1:355a, Abstract No. 1274 (1987).
Johnston, et al., Blood 70(5) Suppl. 1:352a Abstract No. 1264 (1987).
Muller-Eberhard, H., Ann. Rev. Biochem. 57:321-347 (1988).
Bevilacqua, M. P., et al., Science, vol. 243, pp. 1160-1165 (Mar. 3, 1989).
Siegelman, M. H., et al., Science, vol. 243, pp. 1165-1172 (Mar. 3, 1989).
Larsen, E., et al., Cell, vol. 59, 305-312 (Oct. 20, 1989).
Hamburger, S., et al., Blood, vol. 75, No. 3, pp. 550-554 (Feb. 1, 1990).
Johnston, G. I., et al., Cell, vol. 56, 1033-1044 (Mar. 24, 1989).
Brandley, B. K., et al., Cell, vol. 63, 861-863 (Nov. 30, 1990).
Springer, T. A., et al., Nature, vol. 349, pp. 196-197, (Jan. 17, 1991).
Goelz, S. E., et al., Cell, vol. 63, pp. 1349-1356 (Dec. 21, 1990).
Corral, L., et al., Biochem. & Biophy. Res. Comm., vol. 172, No. 3, pp. 1349-1356 (Nov. 15, 1990).
Tiemeyer, M., et al., Proc. Natl. Acad. Sci., vol. 88, pp. 1138-1142 (Feb. 1991).
Lowe, J. B. et al., Cell, vol. 63, pp. 475-484 (Nov. 2, 1990).
Walz, G., et al., Science, vol. 250, pp. 1132-1135 (Nov. 23, 1990).
Phillips, M. L., et al., Science vol. 250, pp. 1130-1131 (Nov. 23, 1990).
Bowen, B. R., et al., J. of Cell Biol., vol. 109, pp. 421-427 (Jul. 1989).
Siegelman, M. H., et al., Proc. Natl. Acad. Sci., vol. 86, pp. 5562-5566 (Jul. 1989).
Tedder, T., et al, J. Exp. Med., vol. 170, pp. 123-133 (Jul. 1989).
Lasky, L. A., et al., Cell, vol. 56, pp. 1045-1055, (Mar. 24, 1989).
Hourcade, D., et al., Advances in Immunology, vol. 45, pp. 381-415 (1989).
Johnston, G. I., et al., J. Biol. Chem., vol. 265, No. 34, pp. 21381-21385 (1990).
Watson, M. L., et al., J. Exp. Med., vol. 172, pp. 263-271 (Jul. 1990).
Hattori, R., et al., J. Biol. Chem., vol. 264, No. 15, pp. 9053-9060. (1989).
Patel, K. D., et al., J. of Cell Biol., vol. 112, No. 4, pp. 749-759 (Feb. 1991).
Bonfanti, R., et al., Blood, vol. 73, No. 5, pp. 1109-1112 (Apr. 1989).
Hattori, R., et al., J. of Biol. Chem., vol. 264, No. 14, pp. 7768-7771. (May 15, 1989).
McEver, R., et al., J. Clin. Invest., vol. 84, pp. 92-99 (Jul. 1989).
Skinner, M. P., et al. Biochem. & Biophys. Res. Comm., vol. 164, pp. 1373-1379 (1989).
Gamble, J. R., et al., Science, vol. 249, pp. 414-417 (Jul. 27, 1990).
Geng, J. G., et al., Nature, vol. 343, No. 6260, pp. 757-760 (Feb. 22, 1990).
Larsen, E., et al., Cell, vol. 63, pp. 467-474, (Nov. 2, 1990).
Moore, et al., J. Cell Biol., vol. 112, pp. 491-499 (1991).
Harris et al "Therapeutic Antibodies-The Coming of Age" Tibtech 11: 42-44 (Feb. 1993).
Berkow, editor, The Merck Manual, 14th-Edition, 1982, pp. 649, 2404, 2405.
Skinner et al., Characterization of Human Platelet GMP-140 as a Heparin-Binding Protein, Biochem. Biophys. Res. Comm. 164:1373-1379, 1989.

Affiliated with

Also associated with

Rating

Modulation of inflammatory responses by administration of GMP-14 does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Modulation of inflammatory responses by administration of GMP-14, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Modulation of inflammatory responses by administration of GMP-14 will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2209840