Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Ester doai
Patent
1997-02-25
2000-08-08
Fay, Zohreh
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Ester doai
A61K 3123
Patent
active
061002968
ABSTRACT:
This invention provides pharmaceutical compositions containing lipoxin compounds and therapeutic uses for the compounds in treating or preventing a disease or condition associated with columnar epithelial inflammation. The invention also discloses methods for screening for compounds useful in preventing columnar epithelial inflammation.
REFERENCES:
patent: 4560514 (1985-12-01), Samuelsson et al.
patent: 4576758 (1986-03-01), Morris
patent: 5049681 (1991-09-01), Sato
patent: 5079261 (1992-01-01), Serhan et al.
Badr, K.F., "15-Lipoxygenase Products as Leukotriene Antagonists: Therapeutic Potential in Glomerulonephritis", Kidney International (1992) vol. 42, Supp. 38, pp. S101-S108.
Dahlen, S-E., "Lipoxins and other Lipoxygenase Products with Relevance to Inflammatory Reactions in the Lung", Annals of the New York Academy of Sciences, Advances in the Understanding and Treatment of Asthma (no date availabel), pp. 262-273.
Fiore, S., "The Lipoxin Biosynthetic Circuit and their Actions with Human Neutrophils" (1991), Advances in Experimental Medicine and Biology, vol. 314, pp. 109-132.
Fiore, S., et al., "Induction of Functional Lipoxin A4 Receptors in HL-60 Cells", Blood (1993), vol. 81, No. 12, pp. 3395-3403.
Lederman, S., et al., "Identification of a Novel Surface Protein on Activated CD4+ T Cells that Induces Contact-Dependent B Cell Differentiation (Help)" J. Exp. Med. (1992), vol. 175, pp. 1091-1101.
Madara, J.L., et al. "A Simple Approach to Measurement of Electrical Parameters of Cultured Epithelial Monolayers: Use in Assessing Neutrophil-Epithelial Interactions", J. Tiss. Cult. Meth. (1992), vol. 14, pp. 209-216.
Madara, J.L. et al., "5'-Adenosine Monophosphate is the Neutrophil-derived Paracrine Factor that Elicits Chloride Secretion from T84 Intestinal Epithelial Cell Monolayers", J. Clin. Invest. (1993), vol. 91, pp. 2320-2325.
Nash, S., et al., "Effects of Polymorphonuclear Leukocyte Transmigration on the Barrier Function of Cultured Intestinal Epithelial Monolayers", J. Clin. Invest. (1987) vol. 80, pp. 1104-1113.
Noelle, R.J., et al. "A 39-kDa Protein on Activated Helper T Cells Binds CD40 and Tranduces the Signal for Cognate Activation of B Cells", Proc. Natl. Acad. Sci. USA (1992) vol. 89, pp. 6550-6554.
Parkos, C.A., et al., "Neutrophil Migration Across a Cultured Intestinal Epithelium", J. Clin. Invest. (1991) vol. 88, pp. 1605-1612.
Parkos, C.A., et al., "Neutrophil Migration Across a Cultured Epithelial Monolayer Elicits a Biphasic Resistance Response Representing Sequential Effects on Transcellular and Paracellular Pathways", The Journal of Cell Biology (1992) vol. 117, No. 4, pp. 757-764.
Pettitt, T.R., et al., "Synthesis of Lipoxins and Other Lipoxygenase Products by Macrophages form the Rainbow Trout, Oncorhynchus Mykiss", The Journal of Biological Chemistry (1991) vol. 266, No. 14, pp. 8720-8726.
Samuelsson, B., "An Elucidation of the Arachidonic Acid Cascade Discovery of Prostaglandins, Thromboxane and Leukotrienes", Drugs (1987) vol. 33, Supp. 1, pp. 2-9.
Serhan, C.N., "Lipoxins: Eicosanoids Carrying Intra-and Intercelular Messages", Journal of Bioenergetics and Biomembranes (1991), vol. 23, No. 1, pp. 105-122.
Nicolaou, K.C., et al., "Identification of a Novel 7-cis 11-Trans-Lipoxin A4 Generated by Human Neutrophils: Total Synthesis, Spasmogenic Activities and Comparison with other Geometric Isomers of Lipoxins A4 and B4", Biochimica et Biophysica Acta (1989) vol. 1003, pp. 44-53.
Nicolaou, K.C., et al., "Total Synthesis of Novel Geometric Isomers of Lipoxin A4 and Lipoxin B4", Journal of Organic Chemistry (1989) vol. 54, pp. 5527-5535.
Nicolaou, K.C., et al., "Lipoxins and Related Eicosanoids: Biosynthesis, Biological Properties and Chemical Synthesis", Agnew. Chem. Int. Ed. Engl. (1991), vol. 30, pp. 1100-1116.
Colgan Sean P.
Madara James L.
Serhan Charles N.
Fay Zohreh
Rothenberger, Esq. Scott D.
The Brigham & Women's Hospital, Inc.
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