Modulation of immunostimulatory activity of...

Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C424S184100, C424S278100

Reexamination Certificate

active

08030462

ABSTRACT:
The invention relates to the therapeutic use of oligonucleotides or oligonucleotide analogs as immunostimulatory agents in immunotherapy applications. The invention provides methods for enhancing the immune response caused by immunostimulatory oligonucleotide compounds.

REFERENCES:
patent: 5149798 (1992-09-01), Agrawal et al.
patent: 5599797 (1997-02-01), Cook et al.
patent: 6562798 (2003-05-01), Schwartz
patent: 7276489 (2007-10-01), Agrawal et al.
patent: 7812000 (2010-10-01), Agrawal et al.
patent: 2002/0137714 (2002-09-01), Kandimalla et al.
patent: 2004/0092468 (2004-05-01), Schwartz
patent: 2005/0026858 (2005-02-01), Kandimalla et al.
patent: 2005/0026861 (2005-02-01), Kandimalla et al.
patent: 2006/0014713 (2006-01-01), Agrawal et al.
patent: 2006/0142224 (2006-06-01), Kandimalla et al.
patent: 2006/0142556 (2006-06-01), Agrawal
patent: 2007/0072198 (2007-03-01), Kandimalla et al.
patent: WO99/62923 (1999-12-01), None
Ozaki et al (1995) Bull. Chem. Soc. Jpn. 68 (1981-1987).
Stein and Cheng. Antisense oligonucleotides as therapeutic agents—is the bullet really magical? Science. Aug. 20, 1993;261(5124):1004-12.
Weiner GJ, Liu HM, Wooldridge JE, Dahle CE, Krieg AM. Immunostimulatory oligodeoxynucleotides containing the CpG motif are effective as immune adjuvants in tumor antigen immunization. Proc Natl Acad Sci U S A. Sep. 30, 1997;94(20):10833-7.
Reese (1978) “The Chemical Synthesis of Oligo- and Poly-Nucleotides By The Phosporotriester Approach,”Tetrahedron34:3143-3179.
Beaucage et al. (1981) “DeoxynucleosIde Phosphoramidites—A New Class of Key Intermediates for Deoxypolynucleotide Synthesis.”Tetrahedron Lett.22:1859-1862.
Connolly et al. (1984) “Synthesis and Characterization of an Octanucleotide Containing the EcoRI Recognition Sequence With a Phosphorothioate Group At The Cleavage Site,” Biochemistry 23:3443.
Agrawal et al. (1987) “Oligodeoxynucleotise Methylphosphonates: Synthesis and Enzymic Degradation,”Tetrahedron Lett.28(31)3539-4542.
Jager et al. (1988) OilgonucleotideN-Alkylphosphoroamidates: Synthesis and Binding to Polynucleotides,Biochemisty27:7237.
Agrawal et al. (1988) Oligodeoxynucleoside Phosphoroamidates and Phosporothioates As inhibitors of Human Immunodeficiency Virus.Proc. Natl. Acad. Scl. USA85:7079-7083.
Zon et al. (1991) “Phosphorothioate Oligorculeotides” Oligoncleotides and Analogues: A Practical Approach pp. 87-108.
Kuramoto et al. (1992) “Oligonucleotide Sequences Required for Natural Killer Cell Activation,”Jpn. J. Cancer Res.83:1128-1131.
Crooke (1993) “An Overview of Progress in Antisense Therapeutics.” 8Antisense&Nucl. Acid Drug Dev.115-122 CRC Press. Boca Raton, Florida.
Zon (1993) “Protocols for Oliognucleotides and Analogs,”Methods in Molecular Biologyvol. 20. pp. 165-189.
Pisetsky at al. (1994)“Stimulation of Murine Lymphocyte Proliferation by a Phosphorothioate Oligonucleotide With Antisense Activity for Herpes Simplex Virus.” 54Life Sci.101.
Yamamoto et al. (1994) “Lipofection of Synthetic Oligodeoxyribonucleotide Having a Palindromic Sequence of AACGTT to Murine Spenocytes Enhances Interferon Production and Natural Killer Activity,” 38Microbiol. Immunol.831.
Agrawal et al. (1995) “Modified Oligonucleotides as Therapeutic and Diagnostic Agents.”Curr.Opin.Biotechnol.6:12-19.
Krieg et al. (1995) “CpG Motifs in Bacterial DNA Trigger Direct B-Cell Activation,”Nature371:546-549.
Klinman et al.(1996) “CpG Motifs Present in Bacterial DNA Rapidly Induce Lymphocytes to Secrete Interleukin 6. Interleukin 12, and Interferon γ,” 93Proc. Natl. Acad. Sci. USA2879.
Liang et al. (1996) “Activation of Human B Cells by Phosphorothioate Oligodeoxynucleotides,”J. Clin Invest.98:1119-1129.
Zhao et al. (1996) “Effect of Different Chemically Modified Oligodeoxynucleotides on Immune Stimulation,”Biochem. Pharm.51:173-182.
Chu et al. (1997) “CpG Oligodeoxynucteolides Act As Adjuvants That Switch on T Helper 1 (Th1) Immunity.” 186J. Exp. Med.1623.
Dunford et al. (1997) “Antisense 97: Targeting the Molecular Basis of Disease” (Nature Biotechnology)Conference Abstract,pp. 40.
Sparwasser et al. (1997) “Macrophages Sense Pathogens Via DNA Motifs: Induction of Tumor Necrosis Factor-α-Mediated Shock.” 27Eur. J. Immunol.1671.
Zhao et al. (1997) “Pattern and Kinetics of Cytokine Production Following Administration of Phosphorothioate Oligonucleotides in Mice.” 7Antisense Nucleic Add Drug. Dev.495.
McCluside et al. (1998) “Cutting Edge: CpG DNA Is A Potent Enhancer of Systemic and Mucosal Immune Responses Against Hepatitis B Surface Antigen with Intranasal Administration to Mice,”J. Immunol.161:4463.4466.
Moldoveanu et al.(1998) “CpG DNA. A Novel Immune Enhancer for Systemic and Mucosal Immunization With Influenza Virus.”Vaccine16:1216-1224.
Sparwasser et al. (1998) “Bacterial DNA and Immunostimulatory CpG Oligonucleotides Trigger Maturation and ACtivation of Murine Dendritic Cells.” 28Eur. J. Immunol.2045.
Tokunaga et al. (1999) “How BCG Led to the Discovery of Immunostimulatory DNA, ” 52Jap. J. Infect. Dis.1.
Zhao et al. (1999) “Site of Chemical Modifications in CpG Containning Phosphorothioate Oligodeoxynucleotide Modulates Its Immunostimulatory Activity,”Bioorg.&Med. Chem. Lett.9:3453-3458.
Agrawal et al. (2000) “Antisense Therapeutics: Is It As Simple As Complementary Base Recognition,” 6Mol. Med. Today72.
Zhao et al. (2000) “Immunostimulatory Activity of CpG Containning Phosphorothioate Oligodeoxynucleotide Is Modulated by Modification of a Single Deoxynucleoside,”Bioorg.&Med. Chem. Lett.10:1051-1054.
Agrawal et al., “Antisense therapeutics”, Curr. Opin. Chem. Biol., 2:519-528, 1998.
Chaix et al., “3′-3′ Linked Oligonucleotides:Synthesis and Stability Studies ”, Biorg. & Med. Chem., 6:827-832, 1996.
Klinman, “therapeutic Applications of CpG-Containing Oli-Godeoxynucleotides”, Antisense & Nucl. Acid Drug Dev., 8:181-184, 1998.
Yu et al., “Accessible 5′-End of CpG-Containing . . . ”, Bioorganic & Medicinal Chemistry Lett., 10:2585-2588, 2000.
Kandimalla et al., “Effect of Chemical Modifications . . . ”, Bioorganic & Medicinal Chemistry, 9:807-813, 2001.
International Search Report (PCT APP. No. PCT/US01/30137).

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Modulation of immunostimulatory activity of... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Modulation of immunostimulatory activity of..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Modulation of immunostimulatory activity of... will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-4283709

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.