Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai
Reexamination Certificate
2005-08-25
2009-11-17
McGarry, Sean R (Department: 1635)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Carbohydrate doai
C435S006120, C435S375000, C435S377000, C536S023100, C536S024100, C536S024500
Reexamination Certificate
active
07618947
ABSTRACT:
Compounds, compositions and methods are provided for modulating the expression of HIF1-beta. The compositions comprise oligonucleotides, targeted to nucleic acid encoding HIF1-beta. Methods of using these compounds for modulation of HIF1-beta expression and for diagnosis and treatment of diseases and conditions associated with expression of HIF1-beta are provided.
REFERENCES:
patent: 5801154 (1998-09-01), Baracchini et al.
patent: 5998148 (1999-12-01), Bennett et al.
patent: 6352829 (2002-03-01), Chenchik et al.
patent: 6582908 (2003-06-01), Fodor et al.
patent: 6627619 (2003-09-01), Cech et al.
patent: 7030236 (2006-04-01), Jhaveri et al.
patent: 2001/0053519 (2001-12-01), Fodor et al.
patent: 2003/0228597 (2003-12-01), Cowsert et al.
patent: 2004/0086498 (2004-05-01), Krissansen et al.
patent: 2004/0096848 (2004-05-01), Thrue et al.
patent: 2004/0101858 (2004-05-01), Ward et al.
patent: 2004/0152655 (2004-08-01), Yoon et al.
patent: 2004/0180357 (2004-09-01), Reich et al.
patent: 2004/0220393 (2004-11-01), Ward et al.
patent: 2005/0070474 (2005-03-01), Krissansen et al.
patent: 2005/0148496 (2005-07-01), Defranoux et al.
patent: 2005/0163781 (2005-07-01), Koninckx et al.
patent: WO 99/48916 (1999-09-01), None
patent: WO 9950403 (1999-10-01), None
patent: WO 02/053735 (2002-07-01), None
patent: WO 2004/048526 (2004-06-01), None
Weintraub, H. Scientific American, pp. 40-46, Jan. 1990.
Furuta et al., Hypoxia-Induced Factor Dependent Induction of Intestinal Trefoil factor Protects Barrier Function During Hypoxia, J.Exp. Med. May 7, 2001, vol. 193, No. 9, pp. 1027-1034.
Gunton et al., Loss or ARNT/HIF1.beta. Mediates Altered Gene Expression and Pancreatic-Islet Dysfunction in Human Type 2 Diabetes, Aug. 12, 2005, vol. 122, pp. 337-349.
Sun et al., Gene transfer of antisense hypoxia inducible factor-1 α enhances the therapeutic efficacy of cancer immunotheraphy, Gene Therapy, 2001, vol. 8, pp. 638-645.
Aplin, J. D., “Hypoxia and human placental development,”J. Clin. Investig.(2000) 105(5):559-560.
Carmeliet, P. et al., “Angiogenesis in cancer and other diseases,”Nature(2000) 407:249-257.
Ebert, B. L. et al., “Hypoxia and Mitochondrial Inhibitors Regulate Expression of Glucose Transporter-1 via Distinct Cis-acting Sequences,”J. Biol. Chem.(1995) 270(49): 29083-29089.
Ema, M. et al., “A novel bHLH-PAS factor with close sequence similarity to hypoxia-inducible factor 1α regulates theVEGFexpression and is potentially involved in lung and vascular development,”Proc. Natl. Acad. Sci. USA(1997) 94:4273-4278.
Gölach, A. et al., “Efficient translation of mouse hypoxia-inducible factor-1α under normoxic and hypoxic conditions,”Biochim. Biophys. Acta(2000) 1493:125-134.
Harris, A. L., “Hypoxia—A Key Regulatory Factor in Tumour Growth,”Nature Rev. Cancer(2002) 2:38-47.
Henry, S. P. et al., “Setting sights on the treatment of ocular angiogenesis using antisense oligonucleotides,”Trends Pharm. Sci.(2004) 25(10): 523-527.
Hoffman, E. C. et al., “Cloning of a Factor Required for Activity of the Ah (Dioxin) Receptor,”Science(1991) 252:954-958.
Hogenesch, J. B. et al., “Characterization of a Subset of the Basic-Helix-Loop-Helix-PAS Superfamily that Interacts with Components of the Dioxin Signaling Pathway,”J. Biol. Chem.(1997) 272(13):8581-8593.
Jewell, U. R. et al., “Induction of HIF-1α in response to hypoxia is instantaneous,”FASEB J.(2001) 15:1312-1314.
Kallio, P. J. et al., “Signal transduction in hypoxic cells: inducible nuclear translocation and recruitment of the CBP/p300 coactivator by the hypoxia-inducible factor-1α,”EMBO J.(1998) 17(22):6573-6586.
Lee, S. H. et al., “Early Expression of Angiogenesis Factors in Acute Myocardial Ischemia and Infarction,”N. Eng. J. Med.(2000) 342:626-633.
Levy, A. P. et al., “Transcriptional Regulation of the Rat Vascular Endothelial Growth Factor Gene by Hypoxia,”J. Biol. Chem.(1995) 270(22):13333-13340.
Maxwell, P. H. et al., “Inducible operation of the erythropoietin 3′ enhancer in multiple cell lines: Evidence for a widespread oxygen-sensing mechanism,”Proc. Natl. Acad. Sci. USA(1993) 90:2423-2427.
Moore, A. W. et al., “A genomewide survey of basic helix-loop-helix factors inDrosophila,” PNAS(2000) 97(19):10436-10441.
Ohtake, F. et al., “Modulation of oestrogen receptor signaling by association with the activated dioxin receptor,”Nature(2003) 423:545-550.
Poland, A. et al., “Evidence that the Binding Species is Receptor for Induction of Aryl Hydrocarbon Hydroxylase,”J. Biol. Chem.(1976) 251(16):4936-4946.
Reisz-Porszasz, S. et al., “Identification of Functional Domains of the Aryl Hydrocarbon Receptor Nuclear Translocator Protein (ARNT),”Mol. Cell. Biol.(1994) 14(9):6075-6086.
Rolfs, A. et al., “Oxygen-regulated Transferrin Expression is Mediated by Hypoxia-inducible Factor-1,”J. Biol. Chem.(1997) 272(32):20055-20062.
Safe, S., “Molecular biology of the Ah receptor and its role in carcinogenesis,”Toxicol. Lett.(2001) 120:1-7.
Safran, M. et al., “HIF hydroxylation and the mammalian oxygen-sensing pathway,”J. Clin. Investig.(2003) 111(6):779-783.
Semenza, G. L., “Hypoxia-inducible factor 1: oxygen homeostasis and disease pathophysiology,”Trends Mol. Med.(2001) 7(8):345-350.
Semenza, G. L. et al., “Transcriptional Regulation of Genes Encoding Glycolytic Enzymes by Hypoxia-inducible Factor 1,”J. Biol. Chem.(1994) 269(38):23757-23763.
Wang, G. L. et al., “General involvement of hypoxia-inducible factor 1 in transcriptional response to hypoxia,”Proc. Natl. Acad. Sci. USA(1993) 90:4304-4308.
Wang, G. L. et al., “Effect of Protein Kinase and Phosphatase Inhibitors on Expression of Hypoxia-Inducible Factor 1,”Biochem. Biophys. Res. Commun.(1995) 216(2):669-675.
Wang, G. L. et al., “Purification and Characterization of Hypoxia-inducible Factor 1,”J. Biol. Chem.(1995) 270(3):1230-1237.
Wang, G. L. et al., “Characterization of Hypoxia-inducible Factor 1 and Regulation of DNA Binding Activity of Hypoxia,”J. Biol. Chem.(1993) 268(29):21513-21518.
Wiesener, M. S. et al., “Induction of Endothelial PAS Domain Protein-1 by Hypoxia: Characterization and Comparison with Hypoxia-Inducible Factor-1α,”Blood(1998) 92(1):2260-2268.
Wood, S. M. et al., “The Role of the Aryl Hydrocarbon Receptor Nuclear Translocator (ARNT) in Hypoxic Induction of Gene Expression,”J. Biol. Chem.(1996) 271(25):15117-15123.
Zhang, L. et al., “Combined Anti-Fetal Liver Kinase 1 Monoclonal Antibody and Continuous Low-Dose Doxorubicin Inhibits Angiogenesis and Growth of Human Soft Tissue Sarcoma Xenografts by Induction of Endothelial Cell Apoptosis,”Cancer Res.(2002) 62:2034-2042.
Branch, “A good antisense molecule is hard to find” TIBS (1998) 23:45-50.
Chin, Andrew “On the Preparation and Utilization of isolated and Purified Oligonucleotides.” Document purportedly located on a CD-ROM and contributed to the public collection of the Katherine R. Everett Law Library of the University of North Carolina on Mar. 14, 2002.
Crooke, S, “Basic Principles of Antisense Therapeutics,” Antisense Research and Applications, Chapter 1, Springer-Verlag Press, Berlin, Heidelberg, New York, p. 3, Jun. 1998.
New England BioLabs, Inc. Catalogue (1998): 121, 284.
Reynolds et al., Rational siRNA design for RNA interference, Mar. 2004, Nature Biotechnology, vol. 22, pp. 326-330.
Sanghvi, Y. Antisense Research & Applications, Ch 15, pp. 274-286, CRC Press, 1993.
International Search Report from PCT/US2005/030513 dated Apr. 19, 2006.
Dobie Kenneth W.
Henry Scott W.
Kim Youngsoo
Marcusson Eric G.
Isis Pharmaceuticals , Inc.
Knobbe Martens Olson & Bear LLP
McGarry Sean R
LandOfFree
Modulation of HIF-1 beta expression does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Modulation of HIF-1 beta expression, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Modulation of HIF-1 beta expression will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-4139932