Chemistry: molecular biology and microbiology – Animal cell – per se ; composition thereof; process of... – Method of regulating cell metabolism or physiology
Reexamination Certificate
2006-05-22
2010-11-09
Dunston, Jennifer (Department: 1636)
Chemistry: molecular biology and microbiology
Animal cell, per se ; composition thereof; process of...
Method of regulating cell metabolism or physiology
C435S006120, C435S375000
Reexamination Certificate
active
07829333
ABSTRACT:
The present invention provides transcription factors associated with the hedgehog signaling pathway that are regulated by dephosphorylation by phosphatases. Hedgehog response elements (HRE) that interact with the dephosphorylated transcription factors are also provided as well as methods for identifying compounds that are phosphatase inhibitors. Methods of treating tumors in a subject by modulating the phosphorylation of the transcription factor are also included.
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Beachy Philip A.
Chen Chien-Huan
Krishnan Venkatesh
Tsai Ming-Jer
Tsai Sophia
Baylor College of Medicine
DLA Piper (LLP) US
Dunston Jennifer
The Johns Hopkins University School of Medicine
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