Modulation of gene expression by combination therapy

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai

Reexamination Certificate

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C435S006120, C435S091100, C435S455000, C435S375000, C536S023100, C536S024500

Reexamination Certificate

active

06953783

ABSTRACT:
The invention relates to the modulation of gene expression. In particular, the invention relates to compositions comprising antisense oligonucleotides which inhibit expression of a gene in operable association with protein effectors of a product of that gene, and methods of using the same.In addition, the invention relates to the modulation of mammalian gene expression regulated by methylation.

REFERENCES:
patent: 5578716 (1996-11-01), Szyf et al.
patent: 6268137 (2001-07-01), Szyf et al.
patent: WO 94 08625 (1994-04-01), None
patent: WO94/08625 (1994-04-01), None
patent: WO97/32589 (1997-09-01), None
patent: WO 97 32589 (1997-09-01), None
patent: WO 97 32604 (1997-09-01), None
patent: WO97/32604 (1997-09-01), None
patent: WO 97 35990 (1997-10-01), None
patent: WO97/44346 (1997-11-01), None
patent: WO 97/44346 (1997-11-01), None
patent: WO 99 15648 (1999-04-01), None
Fournel et al. Journal of Biological Chemistry. August 20, 1999, vol. 274, No. 34, pp. 24250-24256.
Branch, A. D. A good antisense molecule is hard to find. Feb. 1998. TIBS vol. 23, pp. 45-50.
Crooke, S. T. Antisense Research and Application, Chapter 1, Basic Principles of Antisense Therapeutics, (1998) pp. 1-50. Springer-Verlag Press. Berlin. Heidelberg, New York.
Jen et al. Suppression of Gene Expression by Targeted Disruption of Messenger RNA: Available Options and Current Stategies. (2000) Stem Cells. vol. 18, pp. 307-319.
Ju et al. “Increased Drug Sensitivity of Tumor Cells by Manipulation of Cell Cycle Control Genes.” (Jan. 1996), Thesis, University of Southern California, pp. 100-130.
Szyf, M., Pharmacol. Ther. vol. 70, No. 1, 1996, “The DNA Methylation Machinery as a Target for Anticancer Therapy”, pp. 1-37.
Szyf, M. et al., The Journal of Biological Chemistry, vol. 267, No. 15, 1992, “Induction of Myogenic Differentiation by an Expression Vector Encoding the DNA Methyltransferase cDNA sequence in the Antisense Orientation”, pp. 12831-12836.
MacLeod, A. R. et al., The Journal of Biological Chemistry, vol. 270, No. 14, 1995, “Expression of Antisense to DNA Methyltransferase mRNA Induces DNA Demethylation and Inhibits Tumorigenesis”, pp. 8037-8043.
Wu, J.C. et al., The Journal of Biological Chemistry, vol. 262, No. 10, 1987, “Kinetic and Catalytic Mechanism of Hhal Methyltransferase”, pp. 4778-4786.
Bestor, T. et al., J. Mol. Biol., vol. 203, 1988, “Cloning and Sequencing of a cDNA Encoding DNA Methyltransferase of Mouse Cells: The Carboxyl-terminal Domain of the Mammalian Enzymes is Related to Bacterial Restriction Methyltransferases”, pp. 971-983.
Yen, R.W.C. et al., Nucleic Acide Research, vol. 20, No. 9, 1992, “Isolation and characterization of the cDNA encoding human DNA methyltransferase”, pp. 2287-2291.
Yoder, J.A. et al., The Journal of Biological Chemistry, vol. 271, No. 49, 1996, “New 5′ Regions of the Murine and Human Genes for DNA (Cytosine-5)-methyltransferase”, pp. 31092-31097.
Ju et al., “Increased Drug Sensitivity of Tumor Cells by Manipulation of Cell Cycle Control Genes”, Thesis University of Southern California, Jan. 1, 1996, pp. 100-130.
PCT International Search Report, International Application No. PCT/US99/24278: Date of Completion: Mar. 22, 2000, Date of Mailing: Mar. 29, 2000. Authorized Officer: Leherte, C. (5 pages).
Ju et al., “Increased Drug Sensitivity of Tumor Cells by manipulation of Cell Cycle Control Genes”, Thesis Univ. So. California, pp. 100-130, 1996.
Amer. Assoc. for Cancer Res.: Proceedings of the 89thAnnual Meeting of the Am. Assoc. for Cancer Res., New Orleans, 39:416 XP002094749, 1998.

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