Modulation of forkhead box O1A expression

Details Modulation of forkhead box O1A expression Modulation of forkhead box O1A expression

2007-06-12

2007-06-12

McGarry, Sean (Department: 1635)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

C435S006120, C435S091100, C435S171000, C435S032000, C536S023100, C536S024300, C536S024500

Reexamination Certificate

active

10671074

ABSTRACT:
Antisense compounds, compositions and methods are provided for modulating the expression of forkhead box O1A. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding forkhead box O1A. Methods of using these compounds for modulation of forkhead box O1A expression and for treatment of diseases associated with expression of forkhead box O1A are provided, in particular, for methods of treating diabetes.

REFERENCES:
patent: 5576302 (1996-11-01), Cook et al.
patent: 5650278 (1997-07-01), Barr et al.
patent: 5670317 (1997-09-01), Ladanyi et al.
patent: 5801154 (1998-09-01), Baracchini et al.
patent: 5998148 (1999-12-01), Bennett et al.
patent: 2002/0142305 (2002-10-01), Chin et al.
Anderson, et al., “Genes, chromosomes and rhabdomyosarcoma,” Genes Chromosomes Cancer (1999) 26:275-285.
Anderson, et al., “PAX3-FKHR induces morphological change and enhances cellular proliferation and invasion in rhabdomyosarcoma.” Am. J. Pathol. (2001) 159:1089-1096.
Anderson, et al., “Embryonic expression of the tumor-associated PAX3-FKHR fusion protein interferes with the developmental functios of Pax3,” Proc. Natl. Acad. Sci. USA (2001) 98:1589-1594.
Bennicelli, et al., “Mechanism for transcriptional gain of function resulting from chromosal translocation in alveolar rhabdomyosarcoma,” Proc. Natl. Acad. Sci. USA (1996) 93:5455-5459.
Bernasconi, et al., “Induction of apoptosis in rhabdomyosarcoma cells through down-regulation of PAX proteins,” Proc. Natl. Acad. Sci. USA (1996) 93:13164-13169.
Davis, et al., “Fusion genes resulting from alternative chromosomal translocations are overexpressed by gene-specific mechanisms in alveolar rhabdomyosarcoma,” Proc. Natl. Acad. Sci. USA (1997) 94:8047-8051.
Davis, et al., “Structural characterization of the FKHR gene and its rearrangement in alveolar rhabdomyosracoma,” Human Mol. Genet. (1995) 4:2355-2362.
Davis, et al., “Fusion of PAX7 to FKHR by the variant t(1;13)(p. 36:q14) translocation in alveolar rhabdomyosarcoma,” Cancer Res. (1994) 54:2869-2872.
Del Peso et al., “Regulation of the forkhead transcription factor FKHR, but not the PAX3-FKHR fusion protein, by the serine/threonine kinase, Akt,” Oncogene (1999) 18:7328-7333.
Durham, et al., “FKHR binds the insulin response element in the insulin-like growth factor binding protein-1 promoter,” Endocrinology (1999) 140:3140-3146.
Epstein, et al., “Tumor-specific PAX3-FKHR transcription factor, but not PAX3, activates the platelet-deived growth factor alpha receptor,” Mol. Cell. Biol. (1998) 18:4118-4130.
Gajiwala, et al., “Winged helix proteins,” Curr. Opin. Struct. Biol. (2000) 10:110-116.
Galili, et al., “Fusion of a fork head domain gene to PAX3 in the solid tumor alveolar rhabdomyosarcoma,” Nat. Genet. (1993) 5:230-235.
Guo, et al., “Phosphorylation of serine 256 by protein kinase B disrupts transactivation by FKHR and mediates effects of insulinon insulin-like growth factor -binding protein-1 promoter activity through a conserved insulin response sequence,” J. Biol. Chem. (1999) 274:17184-17192.
Margue, et al., “Transcriptional modulation of the anti-apoptotic protein BCL-XL by the paired box transcription factors PAX3 and PAX3/FKHR,” Oncogene (2000) 19:2921-2929.
Nakae, et al., “The forkhead transcription factor Foxo1 (FKHR) confers insulin sensitivity onto glucose-6-phosphatase expression,” J. Clin. Invest. (2001) 108:1359-1367.
Scheidler, et al., “The hybrid PAX3-FKHR fusion protein of alveolar rhabdomyosarcomatransforms fibroblasts in culture,” Proc. Natl. Acad. Sci. USA (1996) 93:9805-9809.
Tang, et al., “Negative regulation of the forkhead transcription factor by FKHR by Akt,” J. Biol. Chem. (1999) 274:16741-16746.
Anderson et al. GenBank Accession No. AF032885.
PCT International Search Report dated Jan. 3, 2005 for application No. PCT/US03/30352.
Chin, Andrew, “On the Preparation and Utilization of Isolated and Purified Oligonucleotides.” Document purportedly located on a CD-ROM and contributed to the public collection of the Katherine R. Everett Law Library of the University of North Carolina on Mar. 14, 2002.

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