Modulation of endothelial cell proliferation with IP-10

Details Modulation of endothelial cell proliferation with IP-10 Modulation of endothelial cell proliferation with IP-10

1995-06-22

1998-10-20

Walsh, Stephen

Drug, bio-affecting and body treating compositions

Lymphokine

514 2, A61K 3819, A61K 3816

Patent

active

058242996

ABSTRACT:
Disclosed are methods for modulating endothelial cell proliferation. Also, disclosed are methods of detecting compounds which inhibit IP-10 and PF4 binding to a HSPG receptor.

REFERENCES:
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Luster et al., ".gamma.-Interferon transcriptionally regulates an early-response gene containing homology to platelet proteins", Nature 315:672-675, 1985.
Gottlieb et al., "Detection of a .gamma. Interferon-induced protein IP-10 in psoriatic plaques", J. Exp. Med. 168:941-948, 1988.
Smoller et al., "Fixed drug eruptions: evidence for a cytokine-mediated process", J. of Cutaneous Pathology 18(1):13-19, 1990.
Taub et al., "Recombinant Human Interferon-inducible protein 10 is a chemoattractant for human monocytes and T lymphocytes and promotes T cell adhesion to endothelial cells", J. Exp. Med. 177:1809-1814, 1993.
Sato et al., "Platelet factor 4 blocks the binding of basic fibroblast growth factor to the receptor and inhibits the spontaneous migration . . . ", Bioch. and Biophy. Res. Comm. 172:595-600, 1990.
Whitson et al., "Platelet factor 4 selectively inhibits binding of TGF-.beta..sub.1 to the type 1 TGF-.beta..sub.1 receptor", J. Cell. Bioch. 47:31-42, 1991.
Kaplan et al., "The expression of a .gamma. Interferon-induced protein (IP-10) in delayed immune responses in human skin", J. Exp. Med. 166:1098-1108, 1987.

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