Chemistry: molecular biology and microbiology – Enzyme – proenzyme; compositions thereof; process for... – Hydrolase
Reexamination Certificate
2007-10-09
2007-10-09
Achutamurthy, P. (Department: 1652)
Chemistry: molecular biology and microbiology
Enzyme , proenzyme; compositions thereof; process for...
Hydrolase
C435S183000, C435S004000, C435S006120, C435S024000, C514S789000, C536S023200, C536S023700, C536S023500
Reexamination Certificate
active
10340578
ABSTRACT:
Methods for identifying agents that can increase or decrease the isopeptidase activity of a COP9 signalsome (CSN) are provided, as are agent identified using such screening assays. In addition, methods of ameliorating a pathologic condition such as a cancer or an autoimmune disease in a subject by modulating the CSN isopeptidase activity are provided, as are medicaments useful for treating a subject having such a condition.
REFERENCES:
patent: 5976796 (1999-11-01), Szalay et al.
patent: 6165731 (2000-12-01), Deshaies et al.
patent: 00/29436 (2000-05-01), None
Zhou et al. The fission yeast COP9/signalosome is involved in cullin modification by ubiquitin-related Ned8p. BMC Biochemistry (2001) 2:7.
Cenciarelli et al., “Identification of a family of human F-box proteins”,Curr. Biol., 9(20):1177-1179; S1-S3 (Oct. 1999).
Chamovitz et al., “JAB1/CSN5 and the COP9 Signalsome: A Complex Situation”,EMBO Reports, 2(2):96-101 (Feb. 2001).
Ciechanover et al., “Ubiquitin-Mediated Proteolysis: Biological Regulation Via Destruction”,BioEssays, 22(5):442-451 (May 2000).
Cope et al., “Role of predicted metalloprotease motif of Jab1/Csn5 in cleavage of Nedd8 from Cul1”,Science, 298(5593):608-611 (Oct. 2002).
Deshaies, “SCF and Cullin/RING H2-Based Ubiquitin Ligases”,Annu. Rev. Cell Dev. Biol., 15:435-467, Annual Review (1999).
Dive et al., “Phosphinic peptide inhibitors as tools in the study of the function of zinc metallopeptidases”,Biochem. Soc. Trans., 28(4):455-460 (2000).
Eytan et al., “Ubiquitin C-terminal hydrolase activity associated with the 26 S protease complex”,J. Biol. Chem., 268(7):4668-4674 (Mar. 1993).
Garber, “Cancer research. Taking garbage in, tossing cancer out?”,Science, 295(5555):612-613 (Jan. 2002).
Glickman et al., “The Regulatory Particle of theSaccharomyces cerevisiaeProteasome”,Molecular and Cellular Biology, 18(6):3149-3162 (Jun. 1998).
Groll et al., “The Eukaryotic 20S Proteaome: A Potential Target for Drug Development”, In DFG-Schwerpunkt, Strktur, Funktion and Regulation des 20S/26S Ubiquitin-Proteasomesystems Kolloquium, May 23-25, 2001, Program Abstract, accessed on Internet Jun. 20, 2002 at www.dfg-sp-ubiquitin.de.
Hicke, “A new ticket for entry into building vesicles-ubiquitin”,Cell, 106(5):527-530 (Sep. 2001).
Kawakami et al., “NEDD8 recruits E2-ubiquitin to SCF E3 ligase”,EMBO J., 20(15):4003-4012 (Aug. 2001).
Lyapina et al., “Promotion of NEDD8-CUL1 Conjugate Cleavage By COP9 Signalsome”,Science, 292(5520):1382-1385 (May 2001).
Meiners et al., “Role of the Ubiquitin-Protease Pathway In Vascular Restenosis—Proteasome Inhibition As A New Therapeutic Approach”, In DFG-Schwerpunkt, Strktur, Funktion and Regulation des 20S/26S Ubiquitin-Proteasomesystems Kolloquium, May 23-25, 2001, Program Abstract, accessed on Internet Jun. 20, 2002 at www.dfg-sp-ubiquitin.de.
Osaka et al., “Covalent modifier NEDD8 is essential for SCF ubiquitin-ligase in fission yeast”,EMBO J., 19(13):3475-3484 (Jul. 2000).
Reiss et al., “Specificity of Binding of NH2-terminal Residue of Proteins to Ubiquitin-Protein Ligase”,J. Biol. Chem., 263(6):2693-2698 (Feb. 1988).
Schwechheimer et al., “Interactions of the COP9 signalsome with the E3 ubiquitin ligase SCFTIRI in mediating auxin response”,Science, 292(5520):1379-1382 (May 2001).
Verma et al., “A proteasome howdunit: the case of the missing signal”,Cell, 101(4):341-344 (May 2000).
Verma et al., “Proteasomal proteomics: identification of nucleotide-sensitive proteasome-interacting proteins by mass spectrometric analysis of affinity-purified proteasomes”,Mol. Biol. Cell, 11(10):3425-3439 (Oct. 2000).
Wei et al., “The COP9 Complex Is Conserved Between Plants and Mammals and Is Related to the 26S Proteasome Regulatory Complex”,Current Biology, 8(16):919-922; S1-S2 (Jul. 1998).
Winston et al., “A family of mammalian F-box proteins”,Curr. Biol., 9(20):1180-1182 (Oct. 1999).
Zhang et al., “Solid-Phase Synthesis and Chemical Ligation of Transmembrane Segments of Rhodopsin”, Peptides: The Wave of the Future, Proceedings of the 2nd International and 17th American Peptide Symposium, Jun. 9-14, 2001, Leble and Houghten, ed., American Peptide Society (2001).
Verma et al., “Role of Rpn11 Metalloprotease in Deubiquitination and Degradation by the 26S Proteasome”,Science, Oct. 2002., 298(5593):611-15.
Ambroggio Xavier I.
Cope Gregory
Deshaies Raymond J.
Verma Rati
Achutamurthy P.
California Institute of Technology
DLA Piper (US) LLP
Pak Yong D.
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