Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1997-09-15
2000-10-10
Eyler, Yvonne
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
514449, 514471, 435 723, A61K 3816, A61K 31335, A01N 4302, A01N 4308
Patent
active
061302015
ABSTRACT:
Methods of identifying compounds that modulate bcl-2 mediated cell death are disclosed. The methods comprise contacting a cell or cell extract with a test compound and detecting the level of bcl-2 phosphorylation compared to the level of bcl-2 phosphorylation in a similar cell or cell extract not contacted with the test compound. Methods of treating an individual susceptible to or suffering from a disease characterized by inhibition of apoptosis are disclosed. The methods comprise administering to such an individual an bcl-2 phosphorylation compound that inhibits dephosphorylation of bcl-2 and/or facilitates phosphorylation of bcl-2. Methods of treating an individual susceptible to or suffering from a diseases characterized by apoptosis are disclosed. The methods comprise administering to such an individual a bcl-2 dephosphorylation compound that inhibits phosphorylation of bcl-2 and/or facilitates dephosphorylation of bcl-2.
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Croce Carlo M.
Haldar Subrata
Eyler Yvonne
Thomas Jefferson University
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