Modulation of animal cellular responses with compositions contai

Details Modulation of animal cellular responses with compositions contai Modulation of animal cellular responses with compositions contai

1990-08-02

1992-09-15

Wax, Robert A.

Drug, bio-affecting and body treating compositions

Lymphokine

Interferon

424 856, 424 857, 424 855, A61K 3766

Patent

active

051476363

ABSTRACT:
Compositions and methods for their use in modulating animal cellular responses are disclosed. The compositions include as an active agent an effective amount of an 8-substitued guanine derivative bonded 9-1' to an aldose having 5 or 6 carbon atoms in the aldose chain. The composition includes a diluent amount of a physiologically tolerable carrier. The guanine derivative is free of electrically charged functioinality, while the 8-substituent has an electron withdrawing inductive effect greater than that of hydrogen and contains fewer than about 15 atoms. Animal cellular responses are modulated by contacting the cells with a composition of this invention.

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