Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai
Patent
1987-02-13
1989-07-18
Hazel, Blondel
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Carbohydrate doai
4352402, 424 858, A61K 3170, C12N 500
Patent
active
048494119
ABSTRACT:
Compositions and methods for their use in modulating animal cellular responses are disclosed. The compositions include as an active agent an effective amount of an 8-substituted guanine derivative bonded 9-1' to an aldose having 5 or 6 carbon atoms in the aldose chain. The composition includes a diluent amount of a physiologically tolerable carrier. The guanine derivative is free of electrically charged functionality, while the 8-substituent has an electron withdrawing inductive effect greater than that of hydrogen and contains fewer than about 15 atoms. Animal cellular responses are modulated by contacting the cells with a composition of this invention.
REFERENCES:
patent: 3498970 (1970-03-01), Yamoda et al.
Goodman et al., Proc. Natl. Acad. Sci., vol. 78, pp. 7604-7608, 1981.
Chemical Abstracts, vol. 71, No. 25, Abstract No. 119619g, 1969.
Chemical Abstracts, vol. 98, No. 3, Abstract No. 15346g, 1983.
Chemical Abstracts, vol. 99, No. 5, Abstract No. 3654g, 1983 Goodman et al., J. Immunology, pp. 2399-2404, 1982.
Goodman Michael G.
Weigle William O.
Hazel Blondel
Scripps Clinic and Research Foundation
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